STRINGSTRING
WNT10B WNT10B ETV6 ETV6 IRF6 IRF6 HOXB4 HOXB4 FGF4 FGF4 ENSECAP00000041377 ENSECAP00000041377 IFT20 IFT20 GLI3 GLI3 TBX3 TBX3 OSR2 OSR2 PTCH1 PTCH1 SART3 SART3 LIG4 LIG4 CDKN2C CDKN2C SFN SFN WNT2B WNT2B SHB SHB YAP1 YAP1 WNT1 WNT1 NF1 NF1 SCRG1 SCRG1 ARIH2 ARIH2 TGFB1 TGFB1 ZNRF3 ZNRF3 HMX2 HMX2 FGF10 FGF10 CTC1 CTC1 FGF2 FGF2 BRCA2 BRCA2 ELL3 ELL3 RARG RARG XRCC5 XRCC5 RARB RARB NES NES SFRP2 SFRP2 BABAM1 BABAM1 OVOL1 OVOL1 RNF43 RNF43 AXIN2 AXIN2 FGF9 FGF9 NR2E1 NR2E1 KDR KDR KDF1 KDF1 TRIM71 TRIM71 BYSL BYSL HOXA3 HOXA3 SOX9 SOX9 CEP120 CEP120 WNT11 WNT11 GBA GBA YTHDF2 YTHDF2 NFIB NFIB TP63 TP63 CD109 CD109 RUNX2 RUNX2 ERCC2 ERCC2 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ETV6ETS variant 6. (452 aa)
IRF6Interferon regulatory factor 6. (467 aa)
HOXB4Homeobox B4. (251 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
ENSECAP00000041377Uncharacterized protein. (132 aa)
IFT20Intraflagellar transport 20. (157 aa)
GLI3GLI family zinc finger 3. (1581 aa)
TBX3T-box transcription factor 3. (745 aa)
OSR2Odd-skipped related transciption factor 2. (288 aa)
PTCH1Patched 1. (1490 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (962 aa)
LIG4DNA ligase. (911 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
SHBSH2 domain-containing protein. (787 aa)
YAP1Yes associated protein 1. (508 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NF1Neurofibromin 1. (3024 aa)
SCRG1Stimulator of chondrogenesis 1. (98 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ZNRF3Zinc and ring finger 3. (936 aa)
HMX2H6 family homeobox 2. (273 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CTC1CST telomere replication complex component 1. (1229 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
BRCA2BRCA2 DNA repair associated. (3442 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
RARGRetinoic acid receptor gamma. (541 aa)
XRCC5X-ray repair cross complementing 5. (733 aa)
RARBRetinoic acid receptor beta. (448 aa)
NESNestin; Belongs to the intermediate filament family. (1795 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
RNF43Ring finger protein 43. (783 aa)
AXIN2Axin 2. (843 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
TRIM71Tripartite motif containing 71. (868 aa)
BYSLBystin like. (437 aa)
HOXA3Homeobox A3. (444 aa)
SOX9SRY-box 9. (509 aa)
CEP120Centrosomal protein 120. (972 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
GBAGlucosylceramidase. (536 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (580 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (571 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CD109CD109 molecule. (1520 aa)
RUNX2Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (769 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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