STRINGSTRING
GLI3 GLI3 WNT1 WNT1 NF1 NF1 HMGB2 HMGB2 KAT7 KAT7 TGFB1 TGFB1 HMX2 HMX2 FGF10 FGF10 FGF2 FGF2 ELL3 ELL3 PDCD2 PDCD2 RARG RARG RARB RARB OVOL1 OVOL1 FGF9 FGF9 ZFP36L1 ZFP36L1 NR2E1 NR2E1 KDR KDR KDF1 KDF1 PIM1 PIM1 FERMT2 FERMT2 CCNE1 CCNE1 HOXA3 HOXA3 SOX9 SOX9 WNT11 WNT11 NOTCH1 NOTCH1 NFIB NFIB TP63 TP63 CD109 CD109 FBLN1 FBLN1 LTBP3 LTBP3 RUNX2 RUNX2 EIF2AK2 EIF2AK2 NF2 NF2 TP53 TP53 WNT10B WNT10B SOX18 SOX18 OSR2 OSR2 IRF6 IRF6 ATXN1L ATXN1L PTPRC PTPRC SOX17 SOX17 DGCR8 DGCR8 VEGFC VEGFC FGF4 FGF4 HMGA2 HMGA2 SOX11 SOX11 TBX3 TBX3 KITLG KITLG FERMT1 FERMT1 PTCH1 PTCH1 CDKN2C CDKN2C GJA1 GJA1 SFN SFN THPO THPO HNRNPU HNRNPU YAP1 YAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLI3GLI family zinc finger 3. (1581 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NF1Neurofibromin 1. (3024 aa)
HMGB2High mobility group box 2. (210 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
HMX2H6 family homeobox 2. (273 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
PDCD2Programmed cell death 2. (344 aa)
RARGRetinoic acid receptor gamma. (541 aa)
RARBRetinoic acid receptor beta. (448 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
FERMT2Fermitin family member 2. (707 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (408 aa)
HOXA3Homeobox A3. (444 aa)
SOX9SRY-box 9. (509 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NOTCH1Notch receptor 1. (2581 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (571 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CD109CD109 molecule. (1520 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (753 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1554 aa)
RUNX2Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (540 aa)
NF2Neurofibromin 2. (637 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SOX18SRY-box transcription factor 18. (383 aa)
OSR2Odd-skipped related transciption factor 2. (288 aa)
IRF6Interferon regulatory factor 6. (467 aa)
ATXN1LAtaxin 1 like. (645 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
SOX17SRY-box transcription factor 17. (406 aa)
DGCR8DGCR8 microprocessor complex subunit. (829 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
HMGA2Uncharacterized protein. (156 aa)
SOX11Transcription factor SOX. (451 aa)
TBX3T-box transcription factor 3. (745 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
FERMT1Fermitin family member 1. (677 aa)
PTCH1Patched 1. (1490 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
THPOThrombopoietin. (350 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
YAP1Yes associated protein 1. (508 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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