STRINGSTRING
ENSECAP00000037584 ENSECAP00000037584 CYB5R4 CYB5R4 GPX3 GPX3 ENSECAP00000050619 ENSECAP00000050619 SESN1 SESN1 CYBB CYBB LOC111772342 LOC111772342 PRDX4 PRDX4 HBA2 HBA2 CAT CAT ENSECAP00000042890 ENSECAP00000042890 SOD3 SOD3 HBA HBA SOD1 SOD1 PMAIP1 PMAIP1 ENSECAP00000040460 ENSECAP00000040460 PXDN PXDN ENSECAP00000038121 ENSECAP00000038121 NCF4 NCF4 SH3PXD2B SH3PXD2B IL19 IL19 IFI6 IFI6 TP53 TP53 NOXO1 NOXO1 NDUFS3 NDUFS3 ENSECAP00000029765 ENSECAP00000029765 XK XK ENSECAP00000026184 ENSECAP00000026184 LOC100068926 LOC100068926 PDGFB PDGFB NOXA1 NOXA1 ND2 ND2 NOX5 NOX5 TPO TPO CCN1 CCN1 NOS2 NOS2 NOS3 NOS3 DUOX1 DUOX1 PLA2R1 PLA2R1 LPO LPO ACOX1 ACOX1 LOC100057612 LOC100057612 PXDNL PXDNL CCS CCS INAVA INAVA LOC100146156 LOC100146156 NOX3 NOX3 NOX1 NOX1 RFK RFK NQO1 NQO1 TIGAR TIGAR YJEFN3 YJEFN3 DUOX2 DUOX2 NDUFA13 NDUFA13 EPX EPX PRDX5 PRDX5 BNIP3 BNIP3 PRDX3 PRDX3 PARK7 PARK7 NDUFS4 NDUFS4 CCN2 CCN2 HBZ HBZ NDUFS1 NDUFS1 VAV1 VAV1 NCF1 NCF1 MT3 MT3 PREX1 PREX1 IMMP2L IMMP2L DUOXA2 DUOXA2 SOD2 SOD2 ATP5IF1 ATP5IF1 PRDX2 PRDX2 LRRK2 LRRK2 CYBA CYBA P2RX7 P2RX7 NOX4 NOX4 SH3PXD2A SH3PXD2A GLS2 GLS2 DUOXA1 DUOXA1 PRDX1 PRDX1 RIPK3 RIPK3 NCF2 NCF2 PDK4 PDK4 MPO MPO FANCC FANCC DDIT4 DDIT4 SESN2 SESN2 F6W654_HORSE F6W654_HORSE NRROS NRROS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSECAP00000037584Uncharacterized protein. (170 aa)
CYB5R4Cytochrome b5 reductase 4. (551 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
ENSECAP00000050619Thioredoxin domain-containing protein. (199 aa)
SESN1Sestrin 1. (551 aa)
CYBBCytochrome b-245 beta chain. (633 aa)
LOC111772342Innate immunity activator protein-like. (888 aa)
PRDX4Peroxiredoxin 4. (301 aa)
HBA2Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
CATCatalase. (598 aa)
ENSECAP00000042890Uncharacterized protein. (145 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (296 aa)
HBAHemoglobin subunit theta-1; Belongs to the globin family. (142 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (171 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
ENSECAP00000040460Uncharacterized protein. (104 aa)
PXDNPeroxidasin. (1596 aa)
ENSECAP00000038121Redoxin domain-containing protein. (157 aa)
NCF4Neutrophil cytosolic factor 4. (441 aa)
SH3PXD2BSH3 and PX domains 2B. (937 aa)
IL19Interleukin 19. (165 aa)
IFI6Interferon alpha inducible protein 6. (132 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
NOXO1NADPH oxidase organizer 1. (388 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (364 aa)
ENSECAP00000029765Flavokinase domain-containing protein. (117 aa)
XKXK-related protein. (498 aa)
ENSECAP00000026184Complex1_30kDa domain-containing protein; Belongs to the complex I 30 kDa subunit family. (255 aa)
LOC100068926Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (186 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
NOXA1NADPH oxidase activator 1. (506 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (346 aa)
NOX5NADPH oxidase 5. (803 aa)
TPOThyroid peroxidase. (925 aa)
CCN1Cellular communication network factor 1. (382 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1247 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
DUOX1Dual oxidase 1. (1551 aa)
PLA2R1Phospholipase A2 receptor 1. (1625 aa)
LPOLactoperoxidase. (711 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
LOC100057612Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (555 aa)
PXDNLPeroxidasin like. (1243 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
INAVAInnate immunity activator. (888 aa)
LOC100146156Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (607 aa)
NOX3NADPH oxidase 3. (568 aa)
NOX1NADPH oxidase 1. (565 aa)
RFKFlavokinase domain-containing protein. (266 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (298 aa)
YJEFN3YjeF N-terminal domain-containing protein. (249 aa)
DUOX2Dual oxidase 2. (1545 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
EPXEosinophil peroxidase. (715 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (151 aa)
BNIP3BCL2 interacting protein 3. (243 aa)
PRDX3Peroxiredoxin 3. (374 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
CCN2Cellular communication network factor 2. (475 aa)
HBZHemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. (142 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1. (690 aa)
VAV1Vav guanine nucleotide exchange factor 1. (918 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1757 aa)
IMMP2LMitochondrial inner membrane protease subunit. (181 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (108 aa)
PRDX2Peroxiredoxin 2. (198 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
NOX4NADPH oxidase 4. (577 aa)
SH3PXD2ASH3 and PX domains 2A. (1128 aa)
GLS2Glutaminase 2. (602 aa)
DUOXA1Dual oxidase maturation factor 1. (342 aa)
PRDX1Peroxiredoxin 1. (199 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (513 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
PDK4Protein-serine/threonine kinase. (447 aa)
MPOMyeloperoxidase. (724 aa)
FANCCFA complementation group C. (623 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
SESN2Sestrin 2. (481 aa)
F6W654_HORSESuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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