(15 nodes) Positive regulation of neutrophil chemotaxis network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	C5AR1	Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	C3AR1	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (484 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	C1QBP	Complement C1q binding protein. (279 aa)
	LOC111770212	C-C motif chemokine. (100 aa)
	LOC100063059	SCY domain-containing protein. (131 aa)
	PDE1B	NCK associated protein 1 like. (1182 aa)
	MOSPD2	Motile sperm domain containing 2. (517 aa)
	THBS4	Thrombospondin 4. (961 aa)
	IL23A	Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	CD74	CD74 molecule. (272 aa)
	MCU	Mitochondrial calcium uniporter. (356 aa)
	RIPOR2	RHO family interacting cell polarization regulator 2. (1224 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR7	LOC100063059	ENSECAP00000003375	ENSECAP00000011903	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.999
CCR7	LOC111770212	ENSECAP00000003375	ENSECAP00000011147	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.999
LOC100063059	CCR7	ENSECAP00000011903	ENSECAP00000003375	SCY domain-containing protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.999
LOC100063059	LOC111770212	ENSECAP00000011903	ENSECAP00000011147	SCY domain-containing protein.	C-C motif chemokine.	0.922
LOC111770212	CCR7	ENSECAP00000011147	ENSECAP00000003375	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.999
LOC111770212	LOC100063059	ENSECAP00000011147	ENSECAP00000011903	C-C motif chemokine.	SCY domain-containing protein.	0.922
PDE1B	RAC2	ENSECAP00000013141	ENSECAP00000036738	NCK associated protein 1 like.	Rac family small GTPase 2.	0.969
RAC2	PDE1B	ENSECAP00000036738	ENSECAP00000013141	Rac family small GTPase 2.	NCK associated protein 1 like.	0.969