(13 nodes) Epithelial cell-cell adhesion network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SERPINB8	Serpin family B member 8; Belongs to the serpin family. (393 aa)
	CLDN7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	CTNNA3	Catenin alpha 3. (895 aa)
	SRF	Serum response factor. (512 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
	VCL	Vinculin. (1284 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (560 aa)
	THBS4	Thrombospondin 4. (961 aa)
	CCN3	Cellular communication network factor 3. (358 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (837 aa)
	PLEKHA7	Pleckstrin homology domain containing A7. (1344 aa)
	CAMSAP3	Calmodulin regulated spectrin associated protein family member 3. (1269 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAMSAP3	PLEKHA7	ENSECAP00000045934	ENSECAP00000036646	Calmodulin regulated spectrin associated protein family member 3.	Pleckstrin homology domain containing A7.	0.507
CTNNA3	VCL	ENSECAP00000006233	ENSECAP00000011648	Catenin alpha 3.	Vinculin.	0.665
ITGB5	THBS4	ENSECAP00000035882	ENSECAP00000017673	Integrin beta; Belongs to the integrin beta chain family.	Thrombospondin 4.	0.770
ITGB5	VCL	ENSECAP00000035882	ENSECAP00000011648	Integrin beta; Belongs to the integrin beta chain family.	Vinculin.	0.959
PLEKHA7	CAMSAP3	ENSECAP00000036646	ENSECAP00000045934	Pleckstrin homology domain containing A7.	Calmodulin regulated spectrin associated protein family member 3.	0.507
THBS4	ITGB5	ENSECAP00000017673	ENSECAP00000035882	Thrombospondin 4.	Integrin beta; Belongs to the integrin beta chain family.	0.770
VCL	CTNNA3	ENSECAP00000011648	ENSECAP00000006233	Vinculin.	Catenin alpha 3.	0.665
VCL	ITGB5	ENSECAP00000011648	ENSECAP00000035882	Vinculin.	Integrin beta; Belongs to the integrin beta chain family.	0.959