STRINGSTRING
ADAR ADAR S100A6 S100A6 IFIH1 IFIH1 TLR8 TLR8 RIOK3 RIOK3 ZC3H12A ZC3H12A VWCE VWCE POU2AF1 POU2AF1 TGFB1 TGFB1 CXCL10 CXCL10 LOC111770212 LOC111770212 F7C0X6_HORSE F7C0X6_HORSE TOMM70 TOMM70 IL21 IL21 PHB2 PHB2 RRP1B RRP1B IRF3 IRF3 GSDME GSDME DDX58 DDX58 EXT1 EXT1 IL12A IL12A LSM14A LSM14A IKBKE IKBKE TLR7 TLR7 HSP90AA1 HSP90AA1 LGALS8 LGALS8 PHB PHB ATF2 ATF2 TLR3 TLR3 WDFY4 WDFY4 IFI6 IFI6 DHX58 DHX58 DDX3X DDX3X CHUK CHUK SMAD3 SMAD3 POU2F2 POU2F2 ENSECAP00000039988 ENSECAP00000039988 FMR1 FMR1 HIF1A HIF1A ENSECAP00000053594 ENSECAP00000053594 CLPB CLPB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADARAdenosine deaminase RNA specific. (1171 aa)
S100A6Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (92 aa)
IFIH1Interferon induced with helicase C domain 1. (1026 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (513 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (615 aa)
VWCEVon Willebrand factor C and EGF domains. (970 aa)
POU2AF1POU class 2 homeobox associating factor 1. (256 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CXCL10C-X-C motif chemokine. (104 aa)
LOC111770212C-C motif chemokine. (100 aa)
F7C0X6_HORSERING-type domain-containing protein. (212 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (606 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
PHB2Prohibitin. (299 aa)
RRP1BRibosomal RNA processing 1B. (756 aa)
IRF3Interferon regulatory factor 3. (426 aa)
GSDMEGasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. (497 aa)
DDX58DExD/H-box helicase 58. (1021 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa)
LSM14ALSM14A mRNA processing body assembly factor. (507 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (835 aa)
LGALS8Galectin. (357 aa)
PHBProhibitin. (297 aa)
ATF2Activating transcription factor 2. (512 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
WDFY4WDFY family member 4. (3196 aa)
IFI6Interferon alpha inducible protein 6. (132 aa)
DHX58DExH-box helicase 58. (762 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (685 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
POU2F2POU domain protein. (620 aa)
ENSECAP00000039988Prohibitin. (299 aa)
FMR1Fragile X mental retardation 1. (632 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
ENSECAP00000053594Uncharacterized protein. (322 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (720 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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