(8 nodes) Xenophagy network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
	LGALS8	Galectin. (357 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (472 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1013 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	CALCOCO2	Calcium binding and coiled-coil domain 2. (502 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (993 aa)
	ATG16L1	Autophagy related 16 like 1. (914 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG16L1	CALCOCO2	ENSECAP00000037586	ENSECAP00000054530	Autophagy related 16 like 1.	Calcium binding and coiled-coil domain 2.	0.615
ATG16L1	NOD1	ENSECAP00000037586	ENSECAP00000042403	Autophagy related 16 like 1.	Nucleotide binding oligomerization domain containing 1.	0.973
ATG16L1	NOD2	ENSECAP00000037586	ENSECAP00000015042	Autophagy related 16 like 1.	Nucleotide binding oligomerization domain containing 2.	0.991
ATG16L1	RIPK2	ENSECAP00000037586	ENSECAP00000033250	Autophagy related 16 like 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.492
ATG16L1	WIPI2	ENSECAP00000037586	ENSECAP00000019684	Autophagy related 16 like 1.	WD repeat domain, phosphoinositide interacting 2.	0.998
CALCOCO2	ATG16L1	ENSECAP00000054530	ENSECAP00000037586	Calcium binding and coiled-coil domain 2.	Autophagy related 16 like 1.	0.615
CALCOCO2	LGALS8	ENSECAP00000054530	ENSECAP00000027879	Calcium binding and coiled-coil domain 2.	Galectin.	0.962
CALCOCO2	WIPI2	ENSECAP00000054530	ENSECAP00000019684	Calcium binding and coiled-coil domain 2.	WD repeat domain, phosphoinositide interacting 2.	0.584
LGALS8	CALCOCO2	ENSECAP00000027879	ENSECAP00000054530	Galectin.	Calcium binding and coiled-coil domain 2.	0.962
NOD1	ATG16L1	ENSECAP00000042403	ENSECAP00000037586	Nucleotide binding oligomerization domain containing 1.	Autophagy related 16 like 1.	0.973
NOD1	NOD2	ENSECAP00000042403	ENSECAP00000015042	Nucleotide binding oligomerization domain containing 1.	Nucleotide binding oligomerization domain containing 2.	0.883
NOD1	RIPK2	ENSECAP00000042403	ENSECAP00000033250	Nucleotide binding oligomerization domain containing 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.944
NOD2	ATG16L1	ENSECAP00000015042	ENSECAP00000037586	Nucleotide binding oligomerization domain containing 2.	Autophagy related 16 like 1.	0.991
NOD2	NOD1	ENSECAP00000015042	ENSECAP00000042403	Nucleotide binding oligomerization domain containing 2.	Nucleotide binding oligomerization domain containing 1.	0.883
NOD2	RIPK2	ENSECAP00000015042	ENSECAP00000033250	Nucleotide binding oligomerization domain containing 2.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.973
RIPK2	ATG16L1	ENSECAP00000033250	ENSECAP00000037586	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	Autophagy related 16 like 1.	0.492
RIPK2	NOD1	ENSECAP00000033250	ENSECAP00000042403	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	Nucleotide binding oligomerization domain containing 1.	0.944
RIPK2	NOD2	ENSECAP00000033250	ENSECAP00000015042	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	Nucleotide binding oligomerization domain containing 2.	0.973
WIPI2	ATG16L1	ENSECAP00000019684	ENSECAP00000037586	WD repeat domain, phosphoinositide interacting 2.	Autophagy related 16 like 1.	0.998
WIPI2	CALCOCO2	ENSECAP00000019684	ENSECAP00000054530	WD repeat domain, phosphoinositide interacting 2.	Calcium binding and coiled-coil domain 2.	0.584