(74 nodes) Regulation of actomyosin structure organization network (Equus caballus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TACSTD2	Tumor associated calcium signal transducer 2. (333 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (923 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1280 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	PPM1E	Protein phosphatase, Mg2+/Mn2+ dependent 1E. (752 aa)
	TSC1	TSC complex subunit 1. (1232 aa)
	BAG4	BCL2 associated athanogene 4. (456 aa)
	WASF2	WASP family member 2. (498 aa)
	MYOC	Myocilin. (490 aa)
	TESK1	Testis associated actin remodelling kinase 1. (628 aa)
	RHPN2	Rhophilin Rho GTPase binding protein 2. (686 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1412 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	EDN1	Endothelin 1. (202 aa)
	CGNL1	Cingulin like 1. (957 aa)
	RGCC	Regulator of cell cycle. (155 aa)
	CORO2B	Coronin; Belongs to the WD repeat coronin family. (480 aa)
	PPM1F	Protein phosphatase, Mg2+/Mn2+ dependent 1F. (448 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	CCN2	Cellular communication network factor 2. (475 aa)
	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1454 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (449 aa)
	SORBS3	Sorbin and SH3 domain containing 3. (719 aa)
	CORO2A	Coronin; Belongs to the WD repeat coronin family. (531 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	S100A10	S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	SYNPO2L	Synaptopodin 2 like. (985 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (225 aa)
	FERMT2	Fermitin family member 2. (707 aa)
	TMEFF2	Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5. (1687 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	GPR65	Psychosine receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (340 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	EPHA1	EPH receptor A1. (976 aa)
	CARMIL1	Capping protein regulator and myosin 1 linker 1. (1432 aa)
	PPFIA1	PTPRF interacting protein alpha 1. (1218 aa)
	LOC111775940	SAM domain-containing protein. (220 aa)
	PIK3R2	Uncharacterized protein. (479 aa)
	ENSECAP00000023457	Uncharacterized protein. (189 aa)
	BBS4	Bardet-Biedl syndrome 4. (531 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	F11R	F11 receptor. (307 aa)
	RHPN1	Rhophilin Rho GTPase binding protein 1. (898 aa)
	LIMCH1	LIM and calponin homology domains 1. (1624 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (793 aa)
	PFN2	Profilin; Belongs to the profilin family. (188 aa)
	ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (1002 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	CCDC88A	Coiled-coil domain containing 88A. (2029 aa)
	TGFB3	Transforming growth factor beta 3. (490 aa)
	NF2	Neurofibromin 2. (637 aa)
	ANKRD23	Ankyrin repeat domain 23. (336 aa)
	TTC8	Tetratricopeptide repeat domain 8. (515 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	ALMS1	ALMS1 centrosome and basal body associated protein. (3822 aa)
	ARHGEF15	Rho guanine nucleotide exchange factor 15. (852 aa)
	EVL	Enah/Vasp-like. (494 aa)
	ARHGAP6	Rho GTPase activating protein 6. (853 aa)
	ECT2	Epithelial cell transforming 2. (1042 aa)
	ARHGEF18	Uncharacterized protein. (1423 aa)
	PHLDB2	Pleckstrin homology like domain family B member 2. (1340 aa)
	LIMK1	LIM domain kinase 1. (789 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1408 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	ARHGAP28	Rho GTPase activating protein 28. (728 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (491 aa)
	WAS	WASP actin nucleation promoting factor. (605 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ARHGEF5	ENSECAP00000031551	ENSECAP00000019233	Tyrosine-protein kinase.	Rho guanine nucleotide exchange factor 5.	0.427
ABL1	EPHA1	ENSECAP00000031551	ENSECAP00000021660	Tyrosine-protein kinase.	EPH receptor A1.	0.929
ABL1	EVL	ENSECAP00000031551	ENSECAP00000039171	Tyrosine-protein kinase.	Enah/Vasp-like.	0.548
ABL1	WASF2	ENSECAP00000031551	ENSECAP00000008318	Tyrosine-protein kinase.	WASP family member 2.	0.425
ALMS1	BBS4	ENSECAP00000038198	ENSECAP00000024106	ALMS1 centrosome and basal body associated protein.	Bardet-Biedl syndrome 4.	0.500
ARAP1	PPM1E	ENSECAP00000014283	ENSECAP00000006248	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.	Protein phosphatase, Mg2+/Mn2+ dependent 1E.	0.594
ARHGAP28	ARHGEF5	ENSECAP00000046878	ENSECAP00000019233	Rho GTPase activating protein 28.	Rho guanine nucleotide exchange factor 5.	0.402
ARHGEF18	ECT2	ENSECAP00000040867	ENSECAP00000039930	Uncharacterized protein.	Epithelial cell transforming 2.	0.741
ARHGEF18	F11R	ENSECAP00000040867	ENSECAP00000025568	Uncharacterized protein.	F11 receptor.	0.435
ARHGEF18	MET	ENSECAP00000040867	ENSECAP00000008993	Uncharacterized protein.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.467
ARHGEF5	ABL1	ENSECAP00000019233	ENSECAP00000031551	Rho guanine nucleotide exchange factor 5.	Tyrosine-protein kinase.	0.427
ARHGEF5	ARHGAP28	ENSECAP00000019233	ENSECAP00000046878	Rho guanine nucleotide exchange factor 5.	Rho GTPase activating protein 28.	0.402
BAG4	PPFIA1	ENSECAP00000008278	ENSECAP00000022985	BCL2 associated athanogene 4.	PTPRF interacting protein alpha 1.	0.635
BBS4	ALMS1	ENSECAP00000024106	ENSECAP00000038198	Bardet-Biedl syndrome 4.	ALMS1 centrosome and basal body associated protein.	0.500
BBS4	TTC8	ENSECAP00000024106	ENSECAP00000035699	Bardet-Biedl syndrome 4.	Tetratricopeptide repeat domain 8.	0.999
BMP10	SMAD4	ENSECAP00000005721	ENSECAP00000025183	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.494
BMP10	TGFBR1	ENSECAP00000005721	ENSECAP00000046228	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.583
BRAF	NF2	ENSECAP00000029059	ENSECAP00000032303	B-Raf proto-oncogene, serine/threonine kinase.	Neurofibromin 2.	0.473
BRAF	PIK3R1	ENSECAP00000029059	ENSECAP00000017836	B-Raf proto-oncogene, serine/threonine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.462
BRAF	SMAD4	ENSECAP00000029059	ENSECAP00000025183	B-Raf proto-oncogene, serine/threonine kinase.	Mothers against decapentaplegic homolog.	0.590