(21 nodes) Positive regulation of purine nucleotide metabolic process network (Equus caballus)

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Your Input:
	PRXL2C	Peroxiredoxin like 2C. (226 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (336 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (298 aa)
	GUCA2A	Guanylate cyclase activator 2A. (111 aa)
	GUCA2B	Guanylate cyclase activator 2B. (112 aa)
	GUCA1C	Guanylate cyclase activator 1C. (210 aa)
	MLXIPL	MLX interacting protein like. (905 aa)
	APP	Amyloid beta precursor protein. (811 aa)
	NCS1	Neuronal calcium sensor 1. (190 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
	BEND3	BEN domain containing 3. (828 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (470 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (839 aa)
	GPD1	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
	GUCA1B	Guanylate cyclase activator 1B. (220 aa)
	GUCA1A	Guanylate cyclase activator 1A. (205 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (757 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	HTR2A	ENSECAP00000019519	ENSECAP00000032673	Amyloid beta precursor protein.	5-hydroxytryptamine receptor 2A.	0.402
APP	INS	ENSECAP00000019519	ENSECAP00000022114	Amyloid beta precursor protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.585
APP	TREM2	ENSECAP00000019519	ENSECAP00000012909	Amyloid beta precursor protein.	Triggering receptor expressed on myeloid cells 2.	0.598
GUCA1A	GUCA1B	ENSECAP00000051243	ENSECAP00000043913	Guanylate cyclase activator 1A.	Guanylate cyclase activator 1B.	0.742
GUCA1A	GUCA1C	ENSECAP00000051243	ENSECAP00000016527	Guanylate cyclase activator 1A.	Guanylate cyclase activator 1C.	0.528
GUCA1B	GUCA1A	ENSECAP00000043913	ENSECAP00000051243	Guanylate cyclase activator 1B.	Guanylate cyclase activator 1A.	0.742
GUCA1B	GUCA1C	ENSECAP00000043913	ENSECAP00000016527	Guanylate cyclase activator 1B.	Guanylate cyclase activator 1C.	0.933
GUCA1C	GUCA1A	ENSECAP00000016527	ENSECAP00000051243	Guanylate cyclase activator 1C.	Guanylate cyclase activator 1A.	0.528
GUCA1C	GUCA1B	ENSECAP00000016527	ENSECAP00000043913	Guanylate cyclase activator 1C.	Guanylate cyclase activator 1B.	0.933
GUCA2A	GUCA2B	ENSECAP00000012956	ENSECAP00000015604	Guanylate cyclase activator 2A.	Guanylate cyclase activator 2B.	0.760
GUCA2B	GUCA2A	ENSECAP00000015604	ENSECAP00000012956	Guanylate cyclase activator 2B.	Guanylate cyclase activator 2A.	0.760
HTR2A	APP	ENSECAP00000032673	ENSECAP00000019519	5-hydroxytryptamine receptor 2A.	Amyloid beta precursor protein.	0.402
IGF1	INS	ENSECAP00000033255	ENSECAP00000022114	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.995
IGF1	INSR	ENSECAP00000033255	ENSECAP00000008032	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Tyrosine-protein kinase receptor.	0.996
IGF1	PPARGC1A	ENSECAP00000033255	ENSECAP00000035922	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	PPARG coactivator 1 alpha.	0.510
INS	APP	ENSECAP00000022114	ENSECAP00000019519	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Amyloid beta precursor protein.	0.585
INS	IGF1	ENSECAP00000022114	ENSECAP00000033255	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.995
INS	INSR	ENSECAP00000022114	ENSECAP00000008032	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.999
INS	PPARGC1A	ENSECAP00000022114	ENSECAP00000035922	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	PPARG coactivator 1 alpha.	0.698
INSR	IGF1	ENSECAP00000008032	ENSECAP00000033255	Tyrosine-protein kinase receptor.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.996