(27 nodes) Regulation of sprouting angiogenesis network (Equus caballus)

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Predicted Interactions

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Your Input:
	RHOJ	Ras homolog family member J. (236 aa)
	LOC100054259	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (346 aa)
	LOC100054308	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (346 aa)
	FUT1	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (370 aa)
	BMPER	BMP binding endothelial regulator. (685 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	SYNJ2BP	PDZ domain-containing protein. (145 aa)
	EPN2	Epsin 2. (640 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	EPN1	Epsin 1. (576 aa)
	JAK1	Tyrosine-protein kinase. (1141 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (94 aa)
	E2F2	E2F transcription factor 2. (549 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (524 aa)
	GLUL	Glutamine synthetase. (373 aa)
	PARP6	Poly [ADP-ribose] polymerase. (630 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (720 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1047 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (585 aa)
	TNN	Tenascin N. (1296 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (685 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1248 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPN1	EPN2	ENSECAP00000013842	ENSECAP00000011753	Epsin 1.	Epsin 2.	0.694
EPN2	EPN1	ENSECAP00000011753	ENSECAP00000013842	Epsin 2.	Epsin 1.	0.694
FGF1	FGF2	ENSECAP00000018264	ENSECAP00000012430	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.637
FGF1	PIK3CB	ENSECAP00000018264	ENSECAP00000021883	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.401
FGF2	FGF1	ENSECAP00000012430	ENSECAP00000018264	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.637
FGF2	IL10	ENSECAP00000012430	ENSECAP00000007097	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.619
FGF2	THBS1	ENSECAP00000012430	ENSECAP00000007423	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Thrombospondin 1.	0.676
IL10	FGF2	ENSECAP00000007097	ENSECAP00000012430	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.619
IL10	JAK1	ENSECAP00000007097	ENSECAP00000016857	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.703
ITGA5	THBS1	ENSECAP00000048172	ENSECAP00000007423	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	Thrombospondin 1.	0.563
JAK1	IL10	ENSECAP00000016857	ENSECAP00000007097	Tyrosine-protein kinase.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.703
JAK1	PIK3CB	ENSECAP00000016857	ENSECAP00000021883	Tyrosine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.944
PDPK1	PIK3CB	ENSECAP00000044458	ENSECAP00000021883	3-phosphoinositide dependent protein kinase 1.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.960
PDPK1	RHOJ	ENSECAP00000044458	ENSECAP00000002569	3-phosphoinositide dependent protein kinase 1.	Ras homolog family member J.	0.406
PIK3CB	FGF1	ENSECAP00000021883	ENSECAP00000018264	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
PIK3CB	JAK1	ENSECAP00000021883	ENSECAP00000016857	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Tyrosine-protein kinase.	0.944
PIK3CB	PDPK1	ENSECAP00000021883	ENSECAP00000044458	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	3-phosphoinositide dependent protein kinase 1.	0.960
PIK3CB	RHOJ	ENSECAP00000021883	ENSECAP00000002569	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Ras homolog family member J.	0.500
RHOJ	PDPK1	ENSECAP00000002569	ENSECAP00000044458	Ras homolog family member J.	3-phosphoinositide dependent protein kinase 1.	0.406
RHOJ	PIK3CB	ENSECAP00000002569	ENSECAP00000021883	Ras homolog family member J.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.500