Your Input: | |||||
TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa) | ||||
DDRGK1 | DDRGK domain containing 1. (315 aa) | ||||
PLCG2 | Phosphoinositide phospholipase C. (1331 aa) | ||||
TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |