STRINGSTRING
ADGRG1 ADGRG1 PTN PTN SMO SMO LHX2 LHX2 ILK ILK KDM2B KDM2B LIMS2 LIMS2 ZNF423 ZNF423 NF2 NF2 TP53 TP53 SKOR2 SKOR2 DMRTA2 DMRTA2 EMX1 EMX1 TOX TOX LRP2 LRP2 DISC1 DISC1 LOC100067177 LOC100067177 RAPGEF1 RAPGEF1 DISP3 DISP3 GLI3 GLI3 ASCL1 ASCL1 SMARCA1 SMARCA1 ITGB1 ITGB1 KDM1A KDM1A HIF1A HIF1A LRRK2 LRRK2 NF1 NF1 OTP OTP CTNNB1 CTNNB1 CEND1 CEND1 KIFAP3 KIFAP3 TAFA3 TAFA3 LHX1 LHX1 DCT DCT SHCBP1 SHCBP1 SMARCD3 SMARCD3 FOXG1 FOXG1 TAFA1 TAFA1 CIP2A CIP2A FGF2 FGF2 DLL4 DLL4 PTPRZ1 PTPRZ1 GLI1 GLI1 ELL3 ELL3 PTBP2 PTBP2 LHX5 LHX5 BTG2 BTG2 FZD3 FZD3 NR2E1 NR2E1 PROX1 PROX1 GPR37L1 GPR37L1 TRIM71 TRIM71 APPL2 APPL2 PAX6 PAX6 ZNF335 ZNF335 VAX1 VAX1 SOX10 SOX10 FOXO3 FOXO3 CDON CDON
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (691 aa)
PTNPleiotrophin. (192 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
LHX2LIM homeobox 2. (406 aa)
ILKIntegrin linked kinase. (452 aa)
KDM2BLysine demethylase 2B. (1265 aa)
LIMS2LIM zinc finger domain containing 2. (476 aa)
ZNF423Zinc finger protein 423. (1352 aa)
NF2Neurofibromin 2. (637 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
SKOR2SKI family transcriptional corepressor 2. (1010 aa)
DMRTA2DMRT like family A2. (536 aa)
EMX1Empty spiracles homeobox 1. (328 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
LRP2LDL receptor related protein 2. (4673 aa)
DISC1DISC1 scaffold protein. (890 aa)
LOC100067177Beta_helix domain-containing protein. (616 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1465 aa)
DISP3Dispatched RND transporter family member 3. (1393 aa)
GLI3GLI family zinc finger 3. (1581 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (325 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1079 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
KDM1ALysine demethylase 1A. (1007 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
NF1Neurofibromin 1. (3024 aa)
OTPOrthopedia homeobox. (325 aa)
CTNNB1Beta catenin 1. (781 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (149 aa)
KIFAP3Kinesin associated protein 3. (793 aa)
TAFA3TAFA chemokine like family member 3. (268 aa)
LHX1LIM homeobox 1. (405 aa)
DCTDopachrome tautomerase. (548 aa)
SHCBP1SHC binding and spindle associated 1. (759 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
FOXG1Forkhead box G1. (531 aa)
TAFA1TAFA chemokine like family member 1. (133 aa)
CIP2ACell proliferation regulating inhibitor of protein phosphatase 2A. (908 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2327 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
PTBP2Polypyrimidine tract binding protein 2. (537 aa)
LHX5LIM homeobox 5. (402 aa)
BTG2BTG anti-proliferation factor 2. (150 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
PROX1Prospero homeobox 1. (737 aa)
GPR37L1G protein-coupled receptor 37 like 1. (482 aa)
TRIM71Tripartite motif containing 71. (868 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
PAX6Paired box 6. (436 aa)
ZNF335Zinc finger protein 335. (1334 aa)
VAX1Ventral anterior homeobox 1. (332 aa)
SOX10SRY-box transcription factor 10. (546 aa)
FOXO3Forkhead box O3. (671 aa)
CDONCell adhesion associated, oncogene regulated. (1283 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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