STRINGSTRING
MMP3 MMP3 AATF AATF PINK1 PINK1 SLC30A10 SLC30A10 VDAC1 VDAC1 COA8 COA8 ATG5 ATG5 MT3 MT3 PARK7 PARK7 BECN1 BECN1 TIGAR TIGAR MPV17L MPV17L HK2 HK2 INS INS SIRT2 SIRT2 TFAP2A TFAP2A LOC100070407 LOC100070407 TP53 TP53 LOC100146242 LOC100146242 BCR BCR PLIN5 PLIN5 PON2 PON2 ABCD1 ABCD1 HIF1A HIF1A PRKN PRKN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (477 aa)
AATFApoptosis antagonizing transcription factor. (566 aa)
PINK1PTEN induced kinase 1. (585 aa)
SLC30A10Solute carrier family 30 member 10. (479 aa)
VDAC1Voltage dependent anion channel 1. (364 aa)
COA8Cytochrome c oxidase assembly factor 8. (205 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
BECN1Beclin 1. (448 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (298 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
HK2Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SIRT2Sirtuin 2. (462 aa)
TFAP2ATranscription factor AP-2 alpha. (449 aa)
LOC100070407ABC transporter domain-containing protein. (230 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
LOC100146242ABC transmembrane type-1 domain-containing protein. (379 aa)
BCRBCR activator of RhoGEF and GTPase. (1325 aa)
PLIN5Perilipin; Belongs to the perilipin family. (457 aa)
PON2Paraoxonase 2. (376 aa)
ABCD1ATP binding cassette subfamily D member 1. (732 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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