node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG5 | BECN1 | ENSECAP00000011693 | ENSECAP00000016069 | Autophagy protein 5; Involved in autophagic vesicle formation. | Beclin 1. | 0.985 |
ATG5 | HIF1A | ENSECAP00000011693 | ENSECAP00000048740 | Autophagy protein 5; Involved in autophagic vesicle formation. | Hypoxia inducible factor 1 subunit alpha. | 0.459 |
ATG5 | INS | ENSECAP00000011693 | ENSECAP00000022114 | Autophagy protein 5; Involved in autophagic vesicle formation. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.464 |
ATG5 | PINK1 | ENSECAP00000011693 | ENSECAP00000007281 | Autophagy protein 5; Involved in autophagic vesicle formation. | PTEN induced kinase 1. | 0.729 |
ATG5 | PRKN | ENSECAP00000011693 | ENSECAP00000054587 | Autophagy protein 5; Involved in autophagic vesicle formation. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.636 |
ATG5 | TP53 | ENSECAP00000011693 | ENSECAP00000032751 | Autophagy protein 5; Involved in autophagic vesicle formation. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.580 |
ATG5 | VDAC1 | ENSECAP00000011693 | ENSECAP00000010473 | Autophagy protein 5; Involved in autophagic vesicle formation. | Voltage dependent anion channel 1. | 0.684 |
BECN1 | ATG5 | ENSECAP00000016069 | ENSECAP00000011693 | Beclin 1. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.985 |
BECN1 | HIF1A | ENSECAP00000016069 | ENSECAP00000048740 | Beclin 1. | Hypoxia inducible factor 1 subunit alpha. | 0.542 |
BECN1 | INS | ENSECAP00000016069 | ENSECAP00000022114 | Beclin 1. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.517 |
BECN1 | PINK1 | ENSECAP00000016069 | ENSECAP00000007281 | Beclin 1. | PTEN induced kinase 1. | 0.991 |
BECN1 | PRKN | ENSECAP00000016069 | ENSECAP00000054587 | Beclin 1. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.921 |
BECN1 | TP53 | ENSECAP00000016069 | ENSECAP00000032751 | Beclin 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.781 |
HIF1A | ATG5 | ENSECAP00000048740 | ENSECAP00000011693 | Hypoxia inducible factor 1 subunit alpha. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.459 |
HIF1A | BECN1 | ENSECAP00000048740 | ENSECAP00000016069 | Hypoxia inducible factor 1 subunit alpha. | Beclin 1. | 0.542 |
HIF1A | HK2 | ENSECAP00000048740 | ENSECAP00000020361 | Hypoxia inducible factor 1 subunit alpha. | Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. | 0.650 |
HIF1A | INS | ENSECAP00000048740 | ENSECAP00000022114 | Hypoxia inducible factor 1 subunit alpha. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.594 |
HIF1A | TP53 | ENSECAP00000048740 | ENSECAP00000032751 | Hypoxia inducible factor 1 subunit alpha. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.888 |
HK2 | HIF1A | ENSECAP00000020361 | ENSECAP00000048740 | Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. | Hypoxia inducible factor 1 subunit alpha. | 0.650 |
HK2 | INS | ENSECAP00000020361 | ENSECAP00000022114 | Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.718 |