18 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB9A	Ras-related protein Rab-9A-like protein. (201 aa)
	CLEC4E	C-type lectin domain family 4 member E. (217 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
	ENSECAP00000042093	SH2 domain-containing protein. (75 aa)
	ENSECAP00000036381	TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
	SLC11A1	Solute carrier family 11 member 1. (648 aa)
	LAMP1	Lysosomal associated membrane protein 1. (608 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
	TLR10	Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (982 aa)
	ANXA3	Annexin. (323 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	CORO6	Coronin; Belongs to the WD repeat coronin family. (472 aa)
	RAB22A	RAB22A, member RAS oncogene family. (204 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (901 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA3	LAMP1	ENSECAP00000016220	ENSECAP00000024558	Annexin.	Lysosomal associated membrane protein 1.	0.584
APPL2	RAB22A	ENSECAP00000018653	ENSECAP00000010637	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB22A, member RAS oncogene family.	0.799
INPP5B	OCRL	ENSECAP00000018142	ENSECAP00000009334	Inositol polyphosphate-5-phosphatase B.	OCRL inositol polyphosphate-5-phosphatase.	0.954
INPP5B	PIP4P1	ENSECAP00000018142	ENSECAP00000008786	Inositol polyphosphate-5-phosphatase B.	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	0.900
INPP5B	PIP4P2	ENSECAP00000018142	ENSECAP00000009919	Inositol polyphosphate-5-phosphatase B.	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	0.903
LAMP1	ANXA3	ENSECAP00000024558	ENSECAP00000016220	Lysosomal associated membrane protein 1.	Annexin.	0.584
OCRL	INPP5B	ENSECAP00000009334	ENSECAP00000018142	OCRL inositol polyphosphate-5-phosphatase.	Inositol polyphosphate-5-phosphatase B.	0.954
OCRL	PIP4P1	ENSECAP00000009334	ENSECAP00000008786	OCRL inositol polyphosphate-5-phosphatase.	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	0.900
OCRL	PIP4P2	ENSECAP00000009334	ENSECAP00000009919	OCRL inositol polyphosphate-5-phosphatase.	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	0.902
PIP4P1	INPP5B	ENSECAP00000008786	ENSECAP00000018142	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	Inositol polyphosphate-5-phosphatase B.	0.900
PIP4P1	OCRL	ENSECAP00000008786	ENSECAP00000009334	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	OCRL inositol polyphosphate-5-phosphatase.	0.900
PIP4P1	PIP4P2	ENSECAP00000008786	ENSECAP00000009919	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	0.901
PIP4P2	INPP5B	ENSECAP00000009919	ENSECAP00000018142	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	Inositol polyphosphate-5-phosphatase B.	0.903
PIP4P2	OCRL	ENSECAP00000009919	ENSECAP00000009334	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	OCRL inositol polyphosphate-5-phosphatase.	0.902
PIP4P2	PIP4P1	ENSECAP00000009919	ENSECAP00000008786	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).	0.901
RAB22A	APPL2	ENSECAP00000010637	ENSECAP00000018653	RAB22A, member RAS oncogene family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.799
RAB22A	RAB9A	ENSECAP00000010637	ENSECAP00000003756	RAB22A, member RAS oncogene family.	Ras-related protein Rab-9A-like protein.	0.460
RAB22A	RAB9B	ENSECAP00000010637	ENSECAP00000019457	RAB22A, member RAS oncogene family.	RAB9B, member RAS oncogene family.	0.472
RAB9A	RAB22A	ENSECAP00000003756	ENSECAP00000010637	Ras-related protein Rab-9A-like protein.	RAB22A, member RAS oncogene family.	0.460
RAB9A	RAB9B	ENSECAP00000003756	ENSECAP00000019457	Ras-related protein Rab-9A-like protein.	RAB9B, member RAS oncogene family.	0.938