STRINGSTRING
CHRNA6 CHRNA6 CHRNB3 CHRNB3 IL18RAP IL18RAP VWC2L VWC2L TLR6 TLR6 CCR9 CCR9 IRS2 IRS2 ITGAE ITGAE LOC100071430 LOC100071430 SCP2D1 SCP2D1 SSTR1 SSTR1 SSTR5 SSTR5 IL28B IL28B CD3G CD3G CNTFR CNTFR SSTR3 SSTR3 CACNG4 CACNG4 CACNG5 CACNG5 CD79A CD79A RAMP2 RAMP2 TRAF5 TRAF5 IRS1 IRS1 SEMA3E SEMA3E IL20RA IL20RA POLN POLN ITGA9 ITGA9 CHRNA9 CHRNA9 RAMP1 RAMP1 CD4 CD4 GABBR2 GABBR2 IL1RL1 IL1RL1 ITGAL ITGAL INSR INSR GRIA4 GRIA4 CNPY3-2 CNPY3-2 GRIK3 GRIK3 CD27 CD27 ITGA4 ITGA4 ZAP70 ZAP70 CD6 CD6 CD63 CD63 ACVR1B ACVR1B IL27RA IL27RA PRF1 PRF1 LOC100069576 LOC100069576 GRIN3A GRIN3A LOC106780847 LOC106780847 AADACL3 AADACL3 IFNLR1 IFNLR1 CALCRL CALCRL LOC100058884 LOC100058884 ITGB7 ITGB7 ITGA8 ITGA8 INSRR INSRR ADAM28 ADAM28 CACNG3 CACNG3 ANGPTL2 ANGPTL2 CHRNB2 CHRNB2 IL6 IL6 IL23R IL23R CD40 CD40 GRIA3 GRIA3 CACNG2 CACNG2 PELO PELO CHRNB1 CHRNB1 GRIK4 GRIK4 CD3D CD3D LOC100060619 LOC100060619 ITGAM ITGAM MCMDC2 MCMDC2 F7A475_HORSE F7A475_HORSE ITGB3 ITGB3 ACVR1 ACVR1 CNIH3 CNIH3 ITGB8 ITGB8 IL13RA1 IL13RA1 CD2 CD2 LIME1 LIME1 ACVR1C ACVR1C LOC100062102 LOC100062102 CSF2RB CSF2RB CD247 CD247 CCL25 CCL25 DIABLO DIABLO HTR3A HTR3A AMHR2 AMHR2 BMPR1A BMPR1A ITGA2B ITGA2B TRAT1 TRAT1 SSTR2 SSTR2 CHRNA5 CHRNA5 IL12RB1 IL12RB1 IGF1R IGF1R ITGB6 ITGB6 GP6 GP6 CHRNA2 CHRNA2 GRIN2B GRIN2B GRM1 GRM1 COL24A1 COL24A1 NLRP13 NLRP13 IL6R IL6R ITGAD ITGAD TSPAN32 TSPAN32 ERBB3 ERBB3 GPR156 GPR156 GRIN1 GRIN1 TFR2 TFR2 F6RD79_HORSE F6RD79_HORSE BMPR2 BMPR2 EMILIN1 EMILIN1 PMP22 PMP22 ITGA2 ITGA2 IL9 IL9 SDCBP SDCBP LOC100060521 LOC100060521 ENSECAP00000024322 ENSECAP00000024322 IL1R1 IL1R1 IL6ST IL6ST ENSECAP00000026030 ENSECAP00000026030 CACNG8 CACNG8 TLR1 TLR1 ENSECAP00000027643 ENSECAP00000027643 OSMR OSMR CD79B CD79B ITGA10 ITGA10 IL1RL2 IL1RL2 GRIK1 GRIK1 ENSECAP00000031453 ENSECAP00000031453 HJV HJV CD3E CD3E ACVRL1 ACVRL1 ENSECAP00000033309 ENSECAP00000033309 ENSECAP00000033515 ENSECAP00000033515 MADCAM1 MADCAM1 NIPAL2 NIPAL2 IL18R1 IL18R1 FAM189A2 FAM189A2 SPN SPN DLG3 DLG3 GRIA2 GRIA2 CNIH2 CNIH2 GP1BB GP1BB LOC102148014 LOC102148014 ITGB5 ITGB5 ENSECAP00000036398 ENSECAP00000036398 ENSECAP00000036770 ENSECAP00000036770 SYK SYK GP1BA GP1BA AASDH AASDH GRIN2D GRIN2D LOC100069009 LOC100069009 GRIN2C GRIN2C LOC100068923 LOC100068923 ENSECAP00000039847 ENSECAP00000039847 ACVR2A ACVR2A ITGA11 ITGA11 IL5RA IL5RA LYN LYN ENSECAP00000042167 ENSECAP00000042167 ITGAV ITGAV RAMP3 RAMP3 GRIK2 GRIK2 TRAF3 TRAF3 BHLHE23 BHLHE23 GRIK5 GRIK5 GRIN3B GRIN3B CHRNA10 CHRNA10 CHRNB4 CHRNB4 TGFBR1 TGFBR1 BMPR1B BMPR1B ITGB1 ITGB1 ENSECAP00000047557 ENSECAP00000047557 COL27A1 COL27A1 GRIN2A GRIN2A NCK1 NCK1 ITGA5 ITGA5 TPD52 TPD52 LOC100058422 LOC100058422 GABBR1 GABBR1 NIPAL3 NIPAL3 ITGA6 ITGA6 ENSECAP00000052283 ENSECAP00000052283 FAM189A1 FAM189A1 LRRTM4 LRRTM4 ENSECAP00000052730 ENSECAP00000052730 ACVR2B ACVR2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (493 aa)
CHRNB3Cholinergic receptor nicotinic beta 3 subunit. (466 aa)
IL18RAPInterleukin 18 receptor accessory protein. (600 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
TLR6Toll-like receptor. (859 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
IRS2Insulin receptor substrate 2. (1401 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1167 aa)
LOC100071430Uncharacterized protein. (191 aa)
SCP2D1SCP2 sterol binding domain containing 1. (151 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (390 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
IL28BUncharacterized protein. (189 aa)
CD3GCD3g molecule. (178 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (420 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
CD79ACD79a molecule. (228 aa)
RAMP2Receptor activity modifying protein 2. (181 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (776 aa)
IL20RAInterleukin 20 receptor subunit alpha. (503 aa)
POLNDNA polymerase nu. (901 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (480 aa)
RAMP1Receptor activity modifying protein 1. (148 aa)
CD4CD4 molecule. (460 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
IL1RL1Interleukin 1 receptor like 1. (560 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1168 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
CNPY3-2Canopy FGF signaling regulator 3. (352 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (919 aa)
CD27CD27 molecule. (257 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CD6CD6 molecule. (673 aa)
CD63Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1224 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
IL27RAInterleukin 27 receptor subunit alpha. (650 aa)
PRF1Perforin 1. (555 aa)
LOC100069576Fibronectin type-III domain-containing protein. (823 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
LOC106780847Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
AADACL3Arylacetamide deacetylase like 3. (419 aa)
IFNLR1Interferon lambda receptor 1. (518 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
LOC100058884Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
INSRRTyrosine-protein kinase receptor. (1334 aa)
ADAM28ADAM metallopeptidase domain 28. (819 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ANGPTL2Angiopoietin like 2. (494 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (504 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IL23RInterleukin 23 receptor. (629 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
PELOIntegrin subunit alpha 1; Belongs to the integrin alpha chain family. (1208 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (504 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
CD3DCD3d molecule. (165 aa)
LOC100060619SCY domain-containing protein. (124 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1142 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
F7A475_HORSEIg-like domain-containing protein. (134 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CNIH3Cornichon family AMPA receptor auxiliary protein 3. (160 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
CD2T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. (347 aa)
LIME1Uncharacterized protein. (267 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
LOC100062102Uncharacterized protein; Belongs to the cytochrome P450 family. (592 aa)
CSF2RBUncharacterized protein. (901 aa)
CD247CD247 molecule. (167 aa)
CCL25C-C motif chemokine ligand 25. (151 aa)
DIABLODiablo IAP-binding mitochondrial protein. (237 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (569 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1108 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (187 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (468 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (718 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (808 aa)
GP6Glycoprotein VI platelet. (335 aa)
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit. (505 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
GRM1Glutamate metabotropic receptor 1. (1200 aa)
COL24A1Collagen type XXIV alpha 1 chain. (1709 aa)
NLRP13NLR family pyrin domain containing 13. (992 aa)
IL6RInterleukin 6 receptor. (471 aa)
ITGADIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1203 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (289 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
GPR156G protein-coupled receptor 156. (814 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1004 aa)
TFR2Transferrin receptor 2. (945 aa)
F6RD79_HORSEIg-like domain-containing protein. (133 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (159 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1301 aa)
IL9Interleukin 9. (147 aa)
SDCBPSyndecan binding protein. (359 aa)
LOC100060521Uncharacterized protein. (510 aa)
ENSECAP00000024322Uncharacterized protein. (143 aa)
IL1R1Interleukin 1 receptor type 1. (578 aa)
IL6STInterleukin 6 signal transducer. (1023 aa)
ENSECAP00000026030Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (409 aa)
TLR1Toll-like receptor. (756 aa)
ENSECAP00000027643Ig-like domain-containing protein. (133 aa)
OSMROncostatin M receptor. (972 aa)
CD79BUncharacterized protein. (125 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
IL1RL2Interleukin 1 receptor like 2. (683 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (949 aa)
ENSECAP00000031453Ig-like domain-containing protein. (134 aa)
HJVHemojuvelin BMP co-receptor. (439 aa)
CD3ECD3e molecule. (246 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
ENSECAP00000033309Ig-like domain-containing protein. (146 aa)
ENSECAP00000033515Ig-like domain-containing protein. (134 aa)
MADCAM1Adhes-Ig_like domain-containing protein. (337 aa)
NIPAL2NIPA like domain containing 2. (416 aa)
IL18R1Interleukin 18 receptor 1. (826 aa)
FAM189A2Family with sequence similarity 189 member A2. (601 aa)
SPNUncharacterized protein. (527 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (208 aa)
LOC102148014Uncharacterized protein. (355 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (837 aa)
ENSECAP00000036398Uncharacterized protein. (143 aa)
ENSECAP00000036770Uncharacterized protein. (133 aa)
SYKTyrosine-protein kinase. (716 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (608 aa)
AASDHAminoadipate-semialdehyde dehydrogenase. (1099 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1384 aa)
LOC100069009Uncharacterized protein. (571 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1226 aa)
LOC100068923Uncharacterized protein. (212 aa)
ENSECAP00000039847Ig-like domain-containing protein. (133 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1224 aa)
IL5RAInterleukin 5 receptor subunit alpha. (480 aa)
LYNTyrosine-protein kinase. (533 aa)
ENSECAP00000042167Ig-like domain-containing protein. (138 aa)
ITGAVFamily with sequence similarity 171 member B; Belongs to the integrin alpha chain family. (1787 aa)
RAMP3Uncharacterized protein. (224 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
BHLHE23Basic helix-loop-helix family member e23. (243 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (980 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1044 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (530 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
ENSECAP00000047557Ig-like domain-containing protein. (186 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1840 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1452 aa)
NCK1Interleukin 20 receptor subunit beta. (484 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1248 aa)
TPD52Uncharacterized protein. (247 aa)
LOC100058422Uncharacterized protein. (266 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (899 aa)
NIPAL3NIPA like domain containing 3. (369 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ENSECAP00000052283Ig-like domain-containing protein. (179 aa)
FAM189A1Family with sequence similarity 189 member A1. (607 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (591 aa)
ENSECAP00000052730Uncharacterized protein. (640 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (577 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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