STRINGSTRING
PIK3AP1 PIK3AP1 ENSECAP00000036381 ENSECAP00000036381 TLR5 TLR5 MYD88 MYD88 TLR6 TLR6 IL18RAP IL18RAP TICAM1 TICAM1 LOC100069988 LOC100069988 IL1RAP IL1RAP LOC100072493 LOC100072493 TLR8 TLR8 IL1RL1 IL1RL1 IL1RAPL2 IL1RAPL2 TLR4 TLR4 TIRAP TIRAP TICAM2 TICAM2 TLR9 TLR9 IL1RAPL1 IL1RAPL1 TLR2 TLR2 TLR10 TLR10 BANK1 BANK1 TLR7 TLR7 IL1R1 IL1R1 TLR1 TLR1 IL1RL2 IL1RL2 TLR3 TLR3 SIGIRR SIGIRR SARM1 SARM1 IL18R1 IL18R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (819 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TLR6Toll-like receptor. (859 aa)
IL18RAPInterleukin 18 receptor accessory protein. (600 aa)
TICAM1Toll like receptor adaptor molecule 1. (698 aa)
LOC100069988TIR domain-containing protein. (949 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
LOC100072493TIR domain-containing protein. (976 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
IL1RL1Interleukin 1 receptor like 1. (560 aa)
IL1RAPL2Interleukin 1 receptor accessory protein like 2. (686 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
TICAM2TIR domain-containing protein. (238 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (696 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (917 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
IL1R1Interleukin 1 receptor type 1. (578 aa)
TLR1Toll-like receptor. (756 aa)
IL1RL2Interleukin 1 receptor like 2. (683 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
SIGIRRSingle Ig and TIR domain containing. (509 aa)
SARM1Sterile alpha and TIR motif containing 1. (877 aa)
IL18R1Interleukin 18 receptor 1. (826 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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