(45 nodes) Low-density lipoprotein (LDL) receptor class A repeat network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMPRSS6	Transmembrane serine protease 6; Belongs to the peptidase S1 family. (808 aa)
	VLDLR	Very low density lipoprotein receptor. (1140 aa)
	SORL1	Sortilin related receptor 1. (2255 aa)
	LRP1B	LDL receptor related protein 1B. (4599 aa)
	LRP12	LDL receptor related protein 12. (858 aa)
	TMPRSS4	Transmembrane serine protease 4; Belongs to the peptidase S1 family. (474 aa)
	LRP8	LDL receptor related protein 8. (1011 aa)
	HSPG2	Heparan sulfate proteoglycan 2. (4395 aa)
	LDLR	Low density lipoprotein receptor. (937 aa)
	TMPRSS7	Transmembrane serine protease 7. (829 aa)
	TMPRSS3	Transmembrane serine protease 3; Belongs to the peptidase S1 family. (454 aa)
	C9	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. (547 aa)
	MALRD1	MAM and LDL receptor class A domain containing 1. (2156 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (306 aa)
	C8A	Complement C8 alpha chain. (589 aa)
	C6	Complement C6. (954 aa)
	LRP1	LDL receptor related protein 1. (4567 aa)
	C7	Complement C7. (910 aa)
	TMPRSS13	Transmembrane serine protease 13; Belongs to the peptidase S1 family. (600 aa)
	LDLRAD2	Low density lipoprotein receptor class A domain containing 2. (340 aa)
	LRP2	LDL receptor related protein 2. (4673 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	C8B	Complement C8 beta chain. (590 aa)
	ALK	Tyrosine-protein kinase receptor. (1623 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
	TMPRSS15	Transmembrane serine protease 15; Belongs to the peptidase S1 family. (1019 aa)
	CORIN	Corin, serine peptidase. (1208 aa)
	NETO2	Neuropilin and tolloid like 2. (525 aa)
	MAMDC4	MAM domain containing 4. (1224 aa)
	LDLRAD3	Low density lipoprotein receptor class A domain containing 3. (512 aa)
	LRP3	LDL receptor related protein 3. (769 aa)
	CD320	CD320 molecule. (267 aa)
	RXFP1	Relaxin family peptide receptor 1. (785 aa)
	CFI	Uncharacterized protein; Belongs to the peptidase S1 family. (630 aa)
	NETO1	Neuropilin and tolloid like 1. (662 aa)
	RXFP2	Relaxin family peptide receptor 2. (739 aa)
	TMPRSS9	Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1181 aa)
	MFRP	Membrane frizzled-related protein. (579 aa)
	LDLRAD1	Low density lipoprotein receptor class A domain containing 1. (204 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (536 aa)
	LRP10	LDL receptor related protein 10. (713 aa)
	LRP4	LDL receptor related protein 4. (1905 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (863 aa)
	ENSECAP00000023688	Uncharacterized protein. (2180 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6	C7	ENSECAP00000047720	ENSECAP00000042966	Complement C6.	Complement C7.	0.560
C6	C8A	ENSECAP00000047720	ENSECAP00000050576	Complement C6.	Complement C8 alpha chain.	0.855
C6	C8B	ENSECAP00000047720	ENSECAP00000037087	Complement C6.	Complement C8 beta chain.	0.866
C6	C9	ENSECAP00000047720	ENSECAP00000006188	Complement C6.	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	0.990
C7	C6	ENSECAP00000042966	ENSECAP00000047720	Complement C7.	Complement C6.	0.560
C7	C8A	ENSECAP00000042966	ENSECAP00000050576	Complement C7.	Complement C8 alpha chain.	0.544
C7	C8B	ENSECAP00000042966	ENSECAP00000037087	Complement C7.	Complement C8 beta chain.	0.540
C7	C9	ENSECAP00000042966	ENSECAP00000006188	Complement C7.	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	0.543
C8A	C6	ENSECAP00000050576	ENSECAP00000047720	Complement C8 alpha chain.	Complement C6.	0.855
C8A	C7	ENSECAP00000050576	ENSECAP00000042966	Complement C8 alpha chain.	Complement C7.	0.544
C8A	C8B	ENSECAP00000050576	ENSECAP00000037087	Complement C8 alpha chain.	Complement C8 beta chain.	0.995
C8A	C9	ENSECAP00000050576	ENSECAP00000006188	Complement C8 alpha chain.	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	0.951
C8B	C6	ENSECAP00000037087	ENSECAP00000047720	Complement C8 beta chain.	Complement C6.	0.866
C8B	C7	ENSECAP00000037087	ENSECAP00000042966	Complement C8 beta chain.	Complement C7.	0.540
C8B	C8A	ENSECAP00000037087	ENSECAP00000050576	Complement C8 beta chain.	Complement C8 alpha chain.	0.995
C8B	C9	ENSECAP00000037087	ENSECAP00000006188	Complement C8 beta chain.	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	0.892
C9	C6	ENSECAP00000006188	ENSECAP00000047720	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	Complement C6.	0.990
C9	C7	ENSECAP00000006188	ENSECAP00000042966	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	Complement C7.	0.543
C9	C8A	ENSECAP00000006188	ENSECAP00000050576	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	Complement C8 alpha chain.	0.951
C9	C8B	ENSECAP00000006188	ENSECAP00000037087	Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.	Complement C8 beta chain.	0.892