STRINGSTRING
LOC111767413 LOC111767413 TMPRSS3 TMPRSS3 HTRA2 HTRA2 LOC111768663 LOC111768663 KLK8 KLK8 HTRA3 HTRA3 F11 F11 PRSS35 PRSS35 TMPRSS7 TMPRSS7 C2 C2 F7 F7 PRSS33 PRSS33 CORIN CORIN TMPRSS15 TMPRSS15 TMPRSS11F TMPRSS11F ST14 ST14 PRSS50 PRSS50 PRSS48 PRSS48 PLAU PLAU FAM111B FAM111B FAM111A FAM111A KLK9 KLK9 F6WB66_HORSE F6WB66_HORSE GZMK GZMK TYSND1 TYSND1 TMPRSS11A TMPRSS11A KLK15 KLK15 TMPRSS12 TMPRSS12 F6XS64_HORSE F6XS64_HORSE C1S C1S TMPRSS11D TMPRSS11D F12 F12 F7C2N1_HORSE F7C2N1_HORSE KLK1E2 KLK1E2 HGF HGF F2 F2 HTRA4 HTRA4 LOC100061896 LOC100061896 CELA1 CELA1 PRSS55 PRSS55 PRSS41 PRSS41 PRSS58 PRSS58 PRSS8 PRSS8 ACR ACR KLK13 KLK13 CFI CFI COX15 COX15 C1RL C1RL LOC100051500 LOC100051500 TMPRSS9 TMPRSS9 LOC100049983 LOC100049983 LOC111768996 LOC111768996 F7DW27_HORSE F7DW27_HORSE KLK14 KLK14 F10 F10 LOC100055297 LOC100055297 LOC100146723 LOC100146723 PRSS22 PRSS22 LOC100067485 LOC100067485 LOC100065003 LOC100065003 PRSS27 PRSS27 PRSS45 PRSS45 PRSS54 PRSS54 PRSS38 PRSS38 LOC100050670 LOC100050670 KLK1 KLK1 LOC100052526 LOC100052526 F9 F9 TPSG1 TPSG1 LOC100067869 LOC100067869 C1R C1R F6Y785_HORSE F6Y785_HORSE MASP2 MASP2 MST1 MST1 TMPRSS2 TMPRSS2 HABP2 HABP2 TMPRSS5 TMPRSS5 GZMA GZMA TMPRSS11E TMPRSS11E TMPRSS11B TMPRSS11B CMA1 CMA1 KLK5 KLK5 LOC100067439 LOC100067439 PROZ PROZ PRSS53 PRSS53 LOC100067932 LOC100067932 LOC102149514 LOC102149514 PRSS56 PRSS56 KLK12 KLK12 TMPRSS6 TMPRSS6 PROC PROC KLK6 KLK6 OVCH2 OVCH2 KLK7 KLK7 ELANE ELANE HTRA1 HTRA1 LOC100071692 LOC100071692 ENSECAP00000029318 ENSECAP00000029318 LOC106782834 LOC106782834 LOC111772536 LOC111772536 PRSS21 PRSS21 TMPRSS4 TMPRSS4 HGFAC HGFAC PRSS37 PRSS37 CTRC CTRC LOC100068723 LOC100068723 LOC100050112 LOC100050112 PRTN3 PRTN3 LOC102150760 LOC102150760 PLG PLG PRSS36 PRSS36 LOC111775413 LOC111775413 CFD CFD LOC100067532 LOC100067532 PRSS12 PRSS12 PRSS57 PRSS57 MASP1 MASP1 HPN HPN PRSS23 PRSS23 RET-2 RET-2 AZU1 AZU1 ENSECAP00000041724 ENSECAP00000041724 TMPRSS13 TMPRSS13 PAMR1 PAMR1 LOC100067368 LOC100067368 ENSECAP00000044250 ENSECAP00000044250 ENSECAP00000044339 ENSECAP00000044339 ENSECAP00000044534 ENSECAP00000044534 PLAT PLAT CFB CFB LOC100052229 LOC100052229 ENSECAP00000047510 ENSECAP00000047510 LOC100049805 LOC100049805 GZMM GZMM CTSG CTSG KLKB1 KLKB1 ENSECAP00000049435 ENSECAP00000049435 ENSECAP00000050589 ENSECAP00000050589 ENSECAP00000051178 ENSECAP00000051178 LOC100051925 LOC100051925 LOC102149070 LOC102149070 LOC100055651 LOC100055651 LOC100050711 LOC100050711 KLK10 KLK10 ENSECAP00000053657 ENSECAP00000053657
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111767413Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (454 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
LOC111768663Peptidase S1 domain-containing protein. (255 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (262 aa)
HTRA3HtrA serine peptidase 3. (493 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (625 aa)
PRSS35Serine protease 35. (413 aa)
TMPRSS7Transmembrane serine protease 7. (829 aa)
C2Complement C2; Belongs to the peptidase S1 family. (704 aa)
F7Coagulation factor VII. (446 aa)
PRSS33Serine protease 33; Belongs to the peptidase S1 family. (278 aa)
CORINCorin, serine peptidase. (1208 aa)
TMPRSS15Transmembrane serine protease 15; Belongs to the peptidase S1 family. (1019 aa)
TMPRSS11FTransmembrane serine protease 11F; Belongs to the peptidase S1 family. (449 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
PRSS50Peptidase S1 domain-containing protein. (416 aa)
PRSS48Serine protease 48; Belongs to the peptidase S1 family. (303 aa)
PLAUPlasminogen activator, urokinase. (433 aa)
FAM111BFamily with sequence similarity 111 member B. (737 aa)
FAM111AFamily with sequence similarity 111 member A. (607 aa)
KLK9Kallikrein F; Belongs to the peptidase S1 family. (251 aa)
F6WB66_HORSEPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (249 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
TYSND1Serine protease; Belongs to the peptidase S1B family. (566 aa)
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (417 aa)
KLK15Kallikrein related peptidase 15; Belongs to the peptidase S1 family. (257 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (298 aa)
F6XS64_HORSEPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (198 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (689 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
F12Coagulation factor XII. (615 aa)
F7C2N1_HORSETransmembrane protease serine; Belongs to the peptidase S1 family. (433 aa)
KLK1E2Kallikrein-1E2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (261 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
HTRA4HtrA serine peptidase 4. (477 aa)
LOC100061896Peptidase S1 domain-containing protein. (270 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (266 aa)
PRSS55Serine protease 55; Belongs to the peptidase S1 family. (350 aa)
PRSS41Serine protease 41; Belongs to the peptidase S1 family. (299 aa)
PRSS58Serine protease 58; Belongs to the peptidase S1 family. (248 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (342 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (402 aa)
KLK13Kallikrein related peptidase 13; Belongs to the peptidase S1 family. (279 aa)
CFIUncharacterized protein; Belongs to the peptidase S1 family. (630 aa)
COX15Cytochrome c oxidase assembly homolog COX15. (413 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (485 aa)
LOC100051500Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
TMPRSS9Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1181 aa)
LOC100049983Uncharacterized protein; Belongs to the peptidase S1 family. (246 aa)
LOC111768996Peptidase S1 domain-containing protein. (252 aa)
F7DW27_HORSEPeptidase S1 domain-containing protein. (134 aa)
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (351 aa)
F10Coagulation factor X. (491 aa)
LOC100055297Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
LOC100146723Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (334 aa)
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (325 aa)
LOC100067485Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa)
LOC100065003Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (490 aa)
PRSS27Serine protease 27; Belongs to the peptidase S1 family. (294 aa)
PRSS45Serine protease 45, pseudogene; Belongs to the peptidase S1 family. (286 aa)
PRSS54Serine protease 54. (386 aa)
PRSS38Serine protease 38; Belongs to the peptidase S1 family. (374 aa)
LOC100050670Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
KLK1Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (261 aa)
LOC100052526Peptidase S1 domain-containing protein. (251 aa)
F9Coagulation factor IX. (457 aa)
TPSG1Tryptase gamma 1. (145 aa)
LOC100067869Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (347 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (705 aa)
F6Y785_HORSEPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (300 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (536 aa)
HABP2Hyaluronan binding protein 2. (611 aa)
TMPRSS5Transmembrane serine protease 5; Belongs to the peptidase S1 family. (512 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (321 aa)
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)
TMPRSS11BTransmembrane protease serine; Belongs to the peptidase S1 family. (417 aa)
CMA1Chymase 1; Belongs to the peptidase S1 family. (245 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (293 aa)
LOC100067439Transmembrane protease serine; Belongs to the peptidase S1 family. (428 aa)
PROZProtein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (400 aa)
PRSS53Serine protease 53; Belongs to the peptidase S1 family. (552 aa)
LOC100067932Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (356 aa)
LOC102149514Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (421 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (606 aa)
KLK12Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (298 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (808 aa)
PROCVitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (640 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (316 aa)
OVCH2Ovochymase 2 (gene/pseudogene); Belongs to the peptidase S1 family. (657 aa)
KLK7Kallikrein related peptidase 7; Belongs to the peptidase S1 family. (257 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (257 aa)
HTRA1HtrA serine peptidase 1. (548 aa)
LOC100071692Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (348 aa)
ENSECAP00000029318Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
LOC106782834Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (265 aa)
LOC111772536Peptidase S1 domain-containing protein. (312 aa)
PRSS21Serine protease 21; Belongs to the peptidase S1 family. (319 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (474 aa)
HGFACHGF activator. (719 aa)
PRSS37Serine protease 37. (251 aa)
CTRCChymotrypsin C; Belongs to the peptidase S1 family. (329 aa)
LOC100068723Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (332 aa)
LOC100050112Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa)
PRTN3Peptidase S1 domain-containing protein. (114 aa)
LOC102150760Peptidase S1 domain-containing protein. (307 aa)
PLGPlasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] (817 aa)
PRSS36Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family. (856 aa)
LOC111775413Peptidase S1 domain-containing protein. (237 aa)
CFDPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (419 aa)
LOC100067532Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (370 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (736 aa)
HPNHepsin; Belongs to the peptidase S1 family. (513 aa)
PRSS23Serine protease 23. (418 aa)
RET-2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (361 aa)
AZU1Azurocidin 1. (251 aa)
ENSECAP00000041724Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (272 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (600 aa)
PAMR1Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family. (875 aa)
LOC100067368Transmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
ENSECAP00000044250Peptidase S1 domain-containing protein. (156 aa)
ENSECAP00000044339Peptidase S1 domain-containing protein. (116 aa)
ENSECAP00000044534Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (239 aa)
PLATPlasminogen activator, tissue type. (615 aa)
CFBUncharacterized protein; Belongs to the peptidase S1 family. (768 aa)
LOC100052229Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (260 aa)
ENSECAP00000047510Peptidase S1 domain-containing protein. (69 aa)
LOC100049805Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
GZMMPeptidase S1 domain-containing protein. (328 aa)
CTSGCathepsin G. (256 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (892 aa)
ENSECAP00000049435Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (145 aa)
ENSECAP00000050589Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (235 aa)
ENSECAP00000051178Peptidase S1 domain-containing protein. (173 aa)
LOC100051925Peptidase S1 domain-containing protein. (240 aa)
LOC102149070Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (268 aa)
LOC100055651Peptidase S1 domain-containing protein. (244 aa)
LOC100050711Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
KLK10Kallikrein related peptidase 10; Belongs to the peptidase S1 family. (292 aa)
ENSECAP00000053657Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (315 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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