STRINGSTRING
IL24 IL24 LOC111767428 LOC111767428 LOC100147174 LOC100147174 LOC100052921 LOC100052921 LOC100064612 LOC100064612 LOC100629885 LOC100629885 CTF1 CTF1 LOC100629951 LOC100629951 LOC100053069 LOC100053069 IFNA1 IFNA1 IL27 IL27 LOC100053110 LOC100053110 ZFP91 ZFP91 IL26 IL26 EPO EPO LEP LEP IL19 IL19 IL20 IL20 LOC100052971 LOC100052971 IFNG IFNG FLT3LG FLT3LG LIF LIF IFN-ALPHA2 IFN-ALPHA2 IL15 IL15 ENSECAP00000024322 ENSECAP00000024322 IL12A IL12A IL23A IL23A IFNK IFNK LOC100065061 LOC100065061 IL22 IL22 CSF1 CSF1 IL5 IL5 IL6 IL6 IL2 IL2 IL21 IL21 IL11 IL11 CLCF1 CLCF1 IL13 IL13 CSF2 CSF2 GH1 GH1 IL10 IL10 CSF3 CSF3 IL4 IL4 IFND1 IFND1 LOC100629859 LOC100629859 LOC100053210 LOC100053210 IFN-OMEGA2 IFN-OMEGA2 F7B4X7_HORSE F7B4X7_HORSE IFNB1 IFNB1 THPO THPO IFNE IFNE LOC100053263 LOC100053263 IFN-OMEGA1 IFN-OMEGA1 IFND2 IFND2 KITLG KITLG PRL PRL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL24Interleukin 24. (206 aa)
LOC111767428Interferon omega-1. (195 aa)
LOC100147174Uncharacterized protein. (186 aa)
LOC100052921Uncharacterized protein. (184 aa)
LOC100064612Uncharacterized protein. (171 aa)
LOC100629885Uncharacterized protein. (167 aa)
CTF1Cardiotrophin 1. (457 aa)
LOC100629951Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa)
LOC100053069Interferon omega-2. (195 aa)
IFNA1Uncharacterized protein. (184 aa)
IL27Interleukin 27. (264 aa)
LOC100053110Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa)
ZFP91Uncharacterized protein. (688 aa)
IL26Interleukin 26. (180 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
IL19Interleukin 19. (165 aa)
IL20Interleukin 20. (248 aa)
LOC100052971Uncharacterized protein. (195 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (241 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
IFN-ALPHA2Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. (184 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (432 aa)
ENSECAP00000024322Uncharacterized protein. (143 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa)
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa)
IFNKInterferon kappa. (208 aa)
LOC100065061Uncharacterized protein. (191 aa)
IL22Interleukin-22-like protein. (189 aa)
CSF1Colony stimulating factor 1. (630 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
IL11Interleukin 11. (246 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
IL13Interleukin-13. (133 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (152 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CSF3Colony stimulating factor 3. (204 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
IFND1Uncharacterized protein. (167 aa)
LOC100629859Uncharacterized protein. (195 aa)
LOC100053210Uncharacterized protein. (184 aa)
IFN-OMEGA2Uncharacterized protein. (195 aa)
F7B4X7_HORSEUncharacterized protein. (113 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
THPOThrombopoietin. (350 aa)
IFNEInterferon epsilon. (171 aa)
LOC100053263Uncharacterized protein. (195 aa)
IFN-OMEGA1Uncharacterized protein. (194 aa)
IFND2Uncharacterized protein. (170 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (234 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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