11 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR6	Toll-like receptor. (859 aa)
	LOC100069988	TIR domain-containing protein. (949 aa)
	LOC100072493	TIR domain-containing protein. (976 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	TLR10	Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
	TLR1	Toll-like receptor. (756 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
	ENSECAP00000036381	TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
	CHADL	Chondroadherin like. (766 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECAP00000036381	TLR1	ENSECAP00000036381	ENSECAP00000026625	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor.	0.913
ENSECAP00000036381	TLR4	ENSECAP00000036381	ENSECAP00000008292	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.658
ENSECAP00000036381	TLR6	ENSECAP00000036381	ENSECAP00000001398	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor.	0.656
TLR1	ENSECAP00000036381	ENSECAP00000026625	ENSECAP00000036381	Toll-like receptor.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.913
TLR1	TLR10	ENSECAP00000026625	ENSECAP00000018320	Toll-like receptor.	Toll like receptor 10; Belongs to the Toll-like receptor family.	0.456
TLR1	TLR2	ENSECAP00000026625	ENSECAP00000015544	Toll-like receptor.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.999
TLR1	TLR3	ENSECAP00000026625	ENSECAP00000032318	Toll-like receptor.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.548
TLR1	TLR4	ENSECAP00000026625	ENSECAP00000008292	Toll-like receptor.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.777
TLR1	TLR5	ENSECAP00000026625	ENSECAP00000039314	Toll-like receptor.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.561
TLR1	TLR6	ENSECAP00000026625	ENSECAP00000001398	Toll-like receptor.	Toll-like receptor.	0.970
TLR10	TLR1	ENSECAP00000018320	ENSECAP00000026625	Toll like receptor 10; Belongs to the Toll-like receptor family.	Toll-like receptor.	0.456
TLR10	TLR2	ENSECAP00000018320	ENSECAP00000015544	Toll like receptor 10; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.671
TLR10	TLR3	ENSECAP00000018320	ENSECAP00000032318	Toll like receptor 10; Belongs to the Toll-like receptor family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.459
TLR10	TLR4	ENSECAP00000018320	ENSECAP00000008292	Toll like receptor 10; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.625
TLR10	TLR5	ENSECAP00000018320	ENSECAP00000039314	Toll like receptor 10; Belongs to the Toll-like receptor family.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.531
TLR2	TLR1	ENSECAP00000015544	ENSECAP00000026625	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll-like receptor.	0.999
TLR2	TLR10	ENSECAP00000015544	ENSECAP00000018320	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll like receptor 10; Belongs to the Toll-like receptor family.	0.671
TLR2	TLR3	ENSECAP00000015544	ENSECAP00000032318	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.705
TLR2	TLR4	ENSECAP00000015544	ENSECAP00000008292	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.987
TLR2	TLR5	ENSECAP00000015544	ENSECAP00000039314	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.955