(16 nodes) SMAD-like domain superfamily network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRF4	Interferon regulatory factor 4. (606 aa)
	SMAD9	Mothers against decapentaplegic homolog. (430 aa)
	SMAD6	Mothers against decapentaplegic homolog. (498 aa)
	IRF3	Interferon regulatory factor 3. (426 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	IRF9	Interferon regulatory factor 9. (394 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SMAD2	Mothers against decapentaplegic homolog. (610 aa)
	IRF6	Interferon regulatory factor 6. (467 aa)
	IRF5	Interferon regulatory factor 5. (683 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	LOC100147208	IRF tryptophan pentad repeat domain-containing protein. (431 aa)
	IRF7	Interferon regulatory factor 7. (536 aa)
	IRF8	Interferon regulatory factor 8. (492 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRF3	IRF7	ENSECAP00000015946	ENSECAP00000047371	Interferon regulatory factor 3.	Interferon regulatory factor 7.	0.969
IRF3	IRF9	ENSECAP00000015946	ENSECAP00000021939	Interferon regulatory factor 3.	Interferon regulatory factor 9.	0.552
IRF3	SMAD3	ENSECAP00000015946	ENSECAP00000039707	Interferon regulatory factor 3.	Mothers against decapentaplegic homolog.	0.467
IRF4	LOC100147208	ENSECAP00000027192	ENSECAP00000043537	Interferon regulatory factor 4.	IRF tryptophan pentad repeat domain-containing protein.	0.900
IRF5	IRF8	ENSECAP00000038212	ENSECAP00000051046	Interferon regulatory factor 5.	Interferon regulatory factor 8.	0.437
IRF7	IRF3	ENSECAP00000047371	ENSECAP00000015946	Interferon regulatory factor 7.	Interferon regulatory factor 3.	0.969
IRF7	IRF9	ENSECAP00000047371	ENSECAP00000021939	Interferon regulatory factor 7.	Interferon regulatory factor 9.	0.427
IRF8	IRF5	ENSECAP00000051046	ENSECAP00000038212	Interferon regulatory factor 8.	Interferon regulatory factor 5.	0.437
IRF9	IRF3	ENSECAP00000021939	ENSECAP00000015946	Interferon regulatory factor 9.	Interferon regulatory factor 3.	0.552
IRF9	IRF7	ENSECAP00000021939	ENSECAP00000047371	Interferon regulatory factor 9.	Interferon regulatory factor 7.	0.427
LOC100147208	IRF4	ENSECAP00000043537	ENSECAP00000027192	IRF tryptophan pentad repeat domain-containing protein.	Interferon regulatory factor 4.	0.900
SMAD1	SMAD2	ENSECAP00000020355	ENSECAP00000029780	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.951
SMAD1	SMAD3	ENSECAP00000020355	ENSECAP00000039707	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.948
SMAD1	SMAD4	ENSECAP00000020355	ENSECAP00000025183	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.999
SMAD1	SMAD5	ENSECAP00000020355	ENSECAP00000016173	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.966
SMAD1	SMAD6	ENSECAP00000020355	ENSECAP00000011390	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.978
SMAD1	SMAD7	ENSECAP00000020355	ENSECAP00000018077	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.949
SMAD1	SMAD9	ENSECAP00000020355	ENSECAP00000010579	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.967
SMAD2	SMAD1	ENSECAP00000029780	ENSECAP00000020355	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.951
SMAD2	SMAD3	ENSECAP00000029780	ENSECAP00000039707	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.999