(16 nodes) Caspase-like domain superfamily network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100069322	Uncharacterized protein; Belongs to the peptidase C14A family. (350 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (347 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (632 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	CASP1	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (478 aa)
	CASP3	Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (510 aa)
	LOC100034070	Uncharacterized protein; Belongs to the peptidase C14A family. (373 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (275 aa)
	MALT1	MALT1 paracaspase. (850 aa)
	CASP4	Uncharacterized protein; Belongs to the peptidase C14A family. (370 aa)
	CASP14	Caspase 14; Belongs to the peptidase C14A family. (242 aa)
	LOC100069290	Uncharacterized protein; Belongs to the peptidase C14A family. (444 aa)
	LOC100068977	Uncharacterized protein; Belongs to the peptidase C14A family. (401 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (464 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	CASP4	ENSECAP00000021890	ENSECAP00000010831	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein; Belongs to the peptidase C14A family.	0.581
CASP1	CASP8	ENSECAP00000021890	ENSECAP00000004066	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Caspase 8; Belongs to the peptidase C14A family.	0.968
CASP1	LOC100069290	ENSECAP00000021890	ENSECAP00000006810	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein; Belongs to the peptidase C14A family.	0.913
CASP1	LOC100069322	ENSECAP00000021890	ENSECAP00000027514	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein; Belongs to the peptidase C14A family.	0.552
CASP10	CASP14	ENSECAP00000021726	ENSECAP00000010379	Caspase 10; Belongs to the peptidase C14A family.	Caspase 14; Belongs to the peptidase C14A family.	0.473
CASP10	CASP2	ENSECAP00000021726	ENSECAP00000030854	Caspase 10; Belongs to the peptidase C14A family.	Caspase 2; Belongs to the peptidase C14A family.	0.630
CASP10	CASP3	ENSECAP00000021726	ENSECAP00000019797	Caspase 10; Belongs to the peptidase C14A family.	Caspase-3-like protein; Belongs to the peptidase C14A family.	0.975
CASP10	CASP6	ENSECAP00000021726	ENSECAP00000013268	Caspase 10; Belongs to the peptidase C14A family.	Caspase 6; Belongs to the peptidase C14A family.	0.725
CASP10	CASP7	ENSECAP00000021726	ENSECAP00000045690	Caspase 10; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.615
CASP10	CASP8	ENSECAP00000021726	ENSECAP00000004066	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.982
CASP10	CASP9	ENSECAP00000021726	ENSECAP00000039254	Caspase 10; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.733
CASP10	CFLAR	ENSECAP00000021726	ENSECAP00000018899	Caspase 10; Belongs to the peptidase C14A family.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.983
CASP10	LOC100034070	ENSECAP00000021726	ENSECAP00000017996	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.508
CASP10	LOC100068977	ENSECAP00000021726	ENSECAP00000006138	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.473
CASP10	LOC100069290	ENSECAP00000021726	ENSECAP00000006810	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.527
CASP10	MALT1	ENSECAP00000021726	ENSECAP00000011434	Caspase 10; Belongs to the peptidase C14A family.	MALT1 paracaspase.	0.659
CASP14	CASP10	ENSECAP00000010379	ENSECAP00000021726	Caspase 14; Belongs to the peptidase C14A family.	Caspase 10; Belongs to the peptidase C14A family.	0.473
CASP14	CASP2	ENSECAP00000010379	ENSECAP00000030854	Caspase 14; Belongs to the peptidase C14A family.	Caspase 2; Belongs to the peptidase C14A family.	0.402
CASP14	CASP8	ENSECAP00000010379	ENSECAP00000004066	Caspase 14; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.490
CASP14	CASP9	ENSECAP00000010379	ENSECAP00000039254	Caspase 14; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.524