STRINGSTRING
TLR8 TLR8 LRRC38 LRRC38 LRRC17 LRRC17 TLR4 TLR4 LRRK2 LRRK2 LRTM1 LRTM1 LRRC8C LRRC8C CHAD CHAD LRIT2 LRIT2 PPP1R42 PPP1R42 ADGRA3 ADGRA3 CHADL CHADL LRRC3B LRRC3B LRIG1 LRIG1 LRRC56 LRRC56 NYX NYX RTN4RL2 RTN4RL2 PKD1 PKD1 SLIT2 SLIT2 LRG1 LRG1 BGN BGN LRFN2 LRFN2 PXDN PXDN TLR5 TLR5 IGFALS IGFALS GP1BA GP1BA ENSECAP00000036381 ENSECAP00000036381 NTRK3 NTRK3 GP1BB GP1BB NTRK1 NTRK1 SLITRK5 SLITRK5 TLR3 TLR3 GP9 GP9 ISLR2 ISLR2 NTRK2 NTRK2 FMOD FMOD LRFN3 LRFN3 SLITRK4 SLITRK4 KERA KERA LINGO3 LINGO3 TRIL TRIL TLR1 TLR1 FLRT1 FLRT1 TLR7 TLR7 ELFN1 ELFN1 LRFN4 LRFN4 LGI1 LGI1 LRRC24 LRRC24 LRRC52 LRRC52 IGSF10 IGSF10 PXDNL PXDNL LRRC4C LRRC4C LGI4 LGI4 TLR10 TLR10 LRIG3 LRIG3 SLITRK2 SLITRK2 DCN DCN LGI3 LGI3 LRRC32 LRRC32 AMIGO2 AMIGO2 LRIG2 LRIG2 LRRC26 LRRC26 LUM LUM PRELP PRELP TLR2 TLR2 FLII FLII MXRA5 MXRA5 CD180 CD180 OMG OMG LGI2 LGI2 LRRC19 LRRC19 PODN PODN LRRC55 LRRC55 LRRN3 LRRN3 LRRC4B LRRC4B OMD OMD TLR9 TLR9 DNAAF1 DNAAF1 LGR4 LGR4 SLITRK6 SLITRK6 SLIT1 SLIT1 FSHR FSHR LINGO4 LINGO4 LRR1 LRR1 LRRC58 LRRC58 ADGRA2 ADGRA2 SLITRK3 SLITRK3 TLR6 TLR6 LRRTM3 LRRTM3 FLRT3 FLRT3 SLITRK1 SLITRK1 LRRC30 LRRC30 LRRN1 LRRN1 LRRC4 LRRC4 GP5 GP5 AMIGO1 AMIGO1 LRIT1 LRIT1 ISLR ISLR VASN VASN RTN4R RTN4R CPN2 CPN2 LRRC3 LRRC3 LOC100069988 LOC100069988 LINGO1 LINGO1 LRRN2 LRRN2 LOC100072493 LOC100072493 SLIT3 SLIT3 ASPN ASPN LRFN1 LRFN1 FLRT2 FLRT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
LRRC38Leucine rich repeat containing 38. (298 aa)
LRRC17Leucine rich repeat containing 17. (441 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
LRTM1Leucine rich repeats and transmembrane domains 1. (339 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit B. (803 aa)
CHADChondroadherin. (359 aa)
LRIT2Leucine rich repeat, Ig-like and transmembrane domains 2. (556 aa)
PPP1R42Protein phosphatase 1 regulatory subunit 42. (309 aa)
ADGRA3Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1313 aa)
CHADLChondroadherin like. (766 aa)
LRRC3BLeucine rich repeat containing 3B. (259 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1094 aa)
LRRC56Leucine rich repeat containing 56. (627 aa)
NYXNyctalopin. (484 aa)
RTN4RL2Reticulon 4 receptor like 2. (420 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4267 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
BGNBiglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (460 aa)
LRFN2Leucine rich repeat and fibronectin type III domain containing 2. (817 aa)
PXDNPeroxidasin. (1596 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (605 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (608 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
NTRK3Tyrosine-protein kinase receptor. (863 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (208 aa)
NTRK1Tyrosine-protein kinase receptor. (880 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
GP9Glycoprotein IX platelet. (177 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (763 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FMODFibromodulin. (392 aa)
LRFN3Leucine rich repeat and fibronectin type III domain containing 3. (628 aa)
SLITRK4SLIT and NTRK like family member 4. (1013 aa)
KERAKeratocan. (389 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (592 aa)
TRILTLR4 interactor with leucine rich repeats. (810 aa)
TLR1Toll-like receptor. (756 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
ELFN1Extracellular leucine rich repeat and fibronectin type III domain containing 1. (825 aa)
LRFN4Leucine rich repeat and fibronectin type III domain containing 4. (636 aa)
LGI1Leucine rich glioma inactivated 1. (641 aa)
LRRC24Leucine rich repeat containing 24. (610 aa)
LRRC52Leucine rich repeat containing 52. (315 aa)
IGSF10Immunoglobulin superfamily member 10. (2611 aa)
PXDNLPeroxidasin like. (1243 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1122 aa)
SLITRK2SLIT and NTRK like family member 2. (845 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
LGI3Leucine rich repeat LGI family member 3. (548 aa)
LRRC32Leucine rich repeat containing 32. (745 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (521 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1023 aa)
LRRC26Leucine rich repeat containing 26. (329 aa)
LUMLumican. (341 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (397 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
FLIIFLII actin remodeling protein. (1270 aa)
MXRA5Matrix remodeling associated 5. (2851 aa)
CD180CD180 molecule. (661 aa)
OMGOligodendrocyte myelin glycoprotein. (443 aa)
LGI2Leucine rich repeat LGI family member 2. (547 aa)
LRRC19Leucine rich repeat containing 19. (368 aa)
PODNPodocan. (617 aa)
LRRC55Leucine rich repeat containing 55. (318 aa)
LRRN3Leucine rich repeat neuronal 3. (708 aa)
LRRC4BLeucine rich repeat containing 4B. (713 aa)
OMDOsteomodulin. (418 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
DNAAF1Dynein assembly factor 1, axonemal. (661 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (1108 aa)
SLITRK6SLIT and NTRK like family member 6. (869 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
LINGO4Leucine rich repeat and Ig domain containing 4. (666 aa)
LRR1Leucine rich repeat protein 1. (413 aa)
LRRC58Leucine rich repeat containing 58. (371 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
SLITRK3SLIT and NTRK like family member 3. (976 aa)
TLR6Toll-like receptor. (859 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (610 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
LRRC30Leucine rich repeat containing 30. (301 aa)
LRRN1Leucine rich repeat neuronal 1. (716 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
GP5Glycoprotein V platelet. (511 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
LRIT1Leucine rich repeat, Ig-like and transmembrane domains 1. (621 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (428 aa)
VASNVasorin. (752 aa)
RTN4RReticulon 4 receptor. (473 aa)
CPN2Carboxypeptidase N subunit 2. (547 aa)
LRRC3Leucine rich repeat containing 3. (257 aa)
LOC100069988TIR domain-containing protein. (949 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
LRRN2Leucine rich repeat neuronal 2. (712 aa)
LOC100072493TIR domain-containing protein. (976 aa)
SLIT3Slit guidance ligand 3. (1521 aa)
ASPNAsporin. (370 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (770 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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