58 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	ENSECAP00000039423	Uncharacterized protein. (111 aa)
	PLCD1	Phosphoinositide phospholipase C. (972 aa)
	MINPP1	Multiple inositol-polyphosphate phosphatase 1; Belongs to the histidine acid phosphatase family. (493 aa)
	PLCL2	Phosphoinositide phospholipase C. (1187 aa)
	LOC111770385	Inositol-tetrakisphosphate 1-kinase. (465 aa)
	PLCZ1	Phospholipase C zeta 1. (534 aa)
	ITPK1	Inositol-tetrakisphosphate 1-kinase. (417 aa)
	PLCH2	Phosphoinositide phospholipase C. (1418 aa)
	PLCG2	Phosphoinositide phospholipase C. (1331 aa)
	PLCH1	Phosphoinositide phospholipase C. (1990 aa)
	ISYNA1	Inositol-3-phosphate synthase 1. (557 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1194 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (982 aa)
	MIOX	Myo-inositol oxygenase. (285 aa)
	IMPA2	Inositol-1-monophosphatase. (293 aa)
	PLCD3	Phosphoinositide phospholipase C. (784 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	PLCE1	Phosphoinositide phospholipase C. (2299 aa)
	IMPA1	Inositol monophosphatase 1. (414 aa)
	INPP1	Inositol polyphosphate-1-phosphatase. (400 aa)
	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1. (646 aa)
	NUDT10	Nudix hydrolase 10. (164 aa)
	IP6K2	Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
	SAMD5	Sterile alpha motif domain containing 5. (169 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (1008 aa)
	ENSECAP00000029759	Nudix hydrolase domain-containing protein. (150 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
	SYNJ1	Synaptojanin 1. (1579 aa)
	INPP5J	Inositol polyphosphate-5-phosphatase J. (1028 aa)
	ITPKC	Kinase; Belongs to the inositol phosphokinase (IPK) family. (666 aa)
	IPMK	Kinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
	IP6K3	Kinase; Belongs to the inositol phosphokinase (IPK) family. (410 aa)
	TASOR	Transcription activation suppressor. (1613 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	INPP4B	Inositol polyphosphate-4-phosphatase type II B. (937 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (901 aa)
	LOC111767502	Phosphoinositide phospholipase C. (534 aa)
	PLCZ1-2	Phosphoinositide phospholipase C. (619 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
	CNOT9	Phosphoinositide phospholipase C. (800 aa)
	IPPK	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (580 aa)
	IP6K1	Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1264 aa)
	PTEN	Phosphatase and tensin homolog. (576 aa)
	PPIP5K1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1532 aa)
	ITPKA	Kinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
	NUDT4	Nudix hydrolase 4. (180 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
	PPIP5K2	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1273 aa)
	PLCL1	Phosphoinositide phospholipase C. (1096 aa)
	NUDT3	Nudix hydrolase 3. (172 aa)
	SASH1	SAM and SH3 domain containing 1. (1234 aa)
	NUDT11	Nudix hydrolase 11. (180 aa)
	UNC50	Inositol polyphosphate-4-phosphatase type I A. (1189 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (462 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM1	CALML3	ENSECAP00000007162	ENSECAP00000004472	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin like 3; Belongs to the calmodulin family.	0.935
CALM1	ITPKA	ENSECAP00000007162	ENSECAP00000016521	Uncharacterized protein; Belongs to the calmodulin family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.901
CALM1	ITPKB	ENSECAP00000007162	ENSECAP00000029379	Uncharacterized protein; Belongs to the calmodulin family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.871
CALM1	ITPKC	ENSECAP00000007162	ENSECAP00000005213	Uncharacterized protein; Belongs to the calmodulin family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.863
CALM1	PLCB1	ENSECAP00000007162	ENSECAP00000018741	Uncharacterized protein; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.915
CALM1	PLCB2	ENSECAP00000007162	ENSECAP00000052392	Uncharacterized protein; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.908
CALM1	PLCB3	ENSECAP00000007162	ENSECAP00000010496	Uncharacterized protein; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.926
CALM1	PLCB4	ENSECAP00000007162	ENSECAP00000030446	Uncharacterized protein; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.914
CALM1	PLCG1	ENSECAP00000007162	ENSECAP00000019222	Uncharacterized protein; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.918
CALM1	PLCG2	ENSECAP00000007162	ENSECAP00000032104	Uncharacterized protein; Belongs to the calmodulin family.	Phosphoinositide phospholipase C.	0.909
CALML3	CALM1	ENSECAP00000004472	ENSECAP00000007162	Calmodulin like 3; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.935
CALML3	ITPKA	ENSECAP00000004472	ENSECAP00000016521	Calmodulin like 3; Belongs to the calmodulin family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.901
CALML3	ITPKB	ENSECAP00000004472	ENSECAP00000029379	Calmodulin like 3; Belongs to the calmodulin family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.871
CALML3	ITPKC	ENSECAP00000004472	ENSECAP00000005213	Calmodulin like 3; Belongs to the calmodulin family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.863
CALML3	PLCB1	ENSECAP00000004472	ENSECAP00000018741	Calmodulin like 3; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.915
CALML3	PLCB2	ENSECAP00000004472	ENSECAP00000052392	Calmodulin like 3; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.908
CALML3	PLCB3	ENSECAP00000004472	ENSECAP00000010496	Calmodulin like 3; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.926
CALML3	PLCB4	ENSECAP00000004472	ENSECAP00000030446	Calmodulin like 3; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.914
CALML3	PLCG1	ENSECAP00000004472	ENSECAP00000019222	Calmodulin like 3; Belongs to the calmodulin family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.918
CALML3	PLCG2	ENSECAP00000004472	ENSECAP00000032104	Calmodulin like 3; Belongs to the calmodulin family.	Phosphoinositide phospholipase C.	0.909