STRINGSTRING
AGER AGER MAP2K7 MAP2K7 S100A12 S100A12 LOC102150222 LOC102150222 NKIRAS1 NKIRAS1 PPP2CB PPP2CB LOC100056819 LOC100056819 F7ANU9_HORSE F7ANU9_HORSE DUSP3 DUSP3 UBE2V1 UBE2V1 LRRC31 LRRC31 S100B S100B RPS6KA3 RPS6KA3 IRAK2 IRAK2 TRAF2 TRAF2 MAPK7 MAPK7 CREB1 CREB1 RELA RELA FOS FOS TONSL TONSL MAPK3 MAPK3 MAPK14 MAPK14 PELI2 PELI2 VWC2 VWC2 NFKB1 NFKB1 ATF1 ATF1 ECSIT ECSIT NOD2 NOD2 FOSL2 FOSL2 NKIRAS2 NKIRAS2 TAB2 TAB2 RPS6KA4 RPS6KA4 RPS27A RPS27A NLRX1 NLRX1 FNBP4 FNBP4 NFKB2 NFKB2 MAPK9 MAPK9 ENSECAP00000035168 ENSECAP00000035168 ATF7 ATF7 UBC-2 UBC-2 DUSP6 DUSP6 LRRC34 LRRC34 CHUK CHUK KHNYN KHNYN MAP2K6 MAP2K6 MAPK15 MAPK15 PELI1 PELI1 ENSECAP00000041260 ENSECAP00000041260 ENSECAP00000041329 ENSECAP00000041329 PELI3 PELI3 NOD1 NOD1 PPP4R1 PPP4R1 LOC100056167 LOC100056167 MAPKAPK3 MAPKAPK3 LOC102148739 LOC102148739 RPS6KA1 RPS6KA1 PPP2R1B PPP2R1B ENSECAP00000044533 ENSECAP00000044533 IRAK1 IRAK1 NLRC5 NLRC5 PPP2R5D PPP2R5D RELCH RELCH TAB3 TAB3 TNIP2 TNIP2 LRRC71 LRRC71 MAPK1 MAPK1 UBE2N UBE2N NFKBIB NFKBIB PPP2R1A PPP2R1A MAPK10 MAPK10 KXD1 KXD1 MAP3K7 MAP3K7 CREB5 CREB5 LRRC45 LRRC45 RPS6KA2 RPS6KA2 VRK3 VRK3 ENSECAP00000023797 ENSECAP00000023797 UBA52 UBA52 MAP2K4 MAP2K4 DUSP7 DUSP7 USP14 USP14 NFKBIA NFKBIA NLRP13 NLRP13 JUN JUN RPS6KA5 RPS6KA5 N4BP1 N4BP1 IKBKG IKBKG TLR10 TLR10 TRAF6 TRAF6 APP APP MAPKAPK2 MAPKAPK2 LRRC14 LRRC14 RIPK2 RIPK2 MAP2K3 MAP2K3 MAP3K1 MAP3K1 IKBKB IKBKB ATF2 ATF2 TAB1 TAB1 NLRP6 NLRP6 PPP4R4 PPP4R4 USP18 USP18 MAP3K20 MAP3K20 UBC UBC F6XH74_HORSE F6XH74_HORSE F6S6S0_HORSE F6S6S0_HORSE DUSP4 DUSP4 CASP8 CASP8 MAPK11 MAPK11 LRRC74A LRRC74A ELK1 ELK1 HMGB1 HMGB1 MAPK8 MAPK8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (494 aa)
S100A12Protein S100; Belongs to the S-100 family. (114 aa)
LOC102150222Ubiquitin-conjugating enzyme E2 N-like protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC100056819Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
F7ANU9_HORSESerum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (134 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (202 aa)
UBE2V1UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
LRRC31Leucine rich repeat containing 31. (562 aa)
S100BProtein S100; Belongs to the S-100 family. (93 aa)
RPS6KA3Ribosomal protein S6 kinase. (747 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (811 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
TONSLTonsoku like, DNA repair protein. (1369 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
ATF1Activating transcription factor 1. (310 aa)
ECSITECSIT signalling integrator. (434 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
RPS27ARibosomal protein S27a. (156 aa)
NLRX1NLR family member X1. (975 aa)
FNBP4Formin binding protein 4. (1021 aa)
NFKB2Nuclear factor kappa B subunit 2. (1024 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
ENSECAP00000035168Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
UBC-2Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (354 aa)
LRRC34Leucine rich repeat containing 34. (448 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
KHNYNKH and NYN domain containing. (666 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (363 aa)
MAPK15Mitogen-activated protein kinase. (630 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (422 aa)
ENSECAP00000041260Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa)
ENSECAP00000041329Uncharacterized protein. (361 aa)
PELI3Pellino E3 ubiquitin protein ligase family member 3. (521 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (967 aa)
LOC100056167WRNPLPNID domain-containing protein. (1089 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (403 aa)
LOC102148739NACHT domain-containing protein. (1069 aa)
RPS6KA1Ribosomal protein S6 kinase. (780 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (783 aa)
ENSECAP00000044533Ubiquitin-like domain-containing protein. (180 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
NLRC5NLR family CARD domain containing 5. (1868 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (697 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1225 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
TNIP2TNFAIP3 interacting protein 2. (592 aa)
LRRC71Leucine rich repeat containing 71. (561 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa)
NFKBIBNFKB inhibitor beta. (371 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (666 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
KXD1KxDL motif containing 1. (194 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
LRRC45Leucine rich repeat containing 45. (695 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
VRK3VRK serine/threonine kinase 3. (403 aa)
ENSECAP00000023797UBIQUITIN_CONJUGAT_2 domain-containing protein. (105 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (531 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (554 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
NLRP13NLR family pyrin domain containing 13. (992 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
RPS6KA5Ribosomal protein S6 kinase. (799 aa)
N4BP1NEDD4 binding protein 1. (897 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
APPAmyloid beta precursor protein. (811 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1672 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
ATF2Activating transcription factor 2. (512 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (971 aa)
USP18USP domain-containing protein; Belongs to the peptidase C19 family. (374 aa)
MAP3K20Uncharacterized protein. (850 aa)
UBCUbiquitin B. (305 aa)
F6XH74_HORSEUncharacterized protein. (215 aa)
F6S6S0_HORSEUncharacterized protein. (212 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (411 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (464 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
ELK1ETS transcription factor ELK1. (432 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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