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| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 3. (604 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (695 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | VRK3 | VRK serine/threonine kinase 3. (403 aa) |
| | TLR8 | Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (494 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1402 aa) |
| | TLR6 | Toll-like receptor. (859 aa) |
| | LOC111767791 | CD14 molecule. (376 aa) |
| | MAP3K20 | Uncharacterized protein. (850 aa) |
| | USP18 | USP domain-containing protein; Belongs to the peptidase C19 family. (374 aa) |
| | UBC | Ubiquitin B. (305 aa) |
| | LOC102150222 | Ubiquitin-conjugating enzyme E2 N-like protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (192 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (89 aa) |
| | LGMN | Legumain. (433 aa) |
| | CNPY3 | Canopy FGF signaling regulator 3. (283 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | LOC100056819 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa) |
| | F7ANU9_HORSE | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (134 aa) |
| | DUSP3 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (202 aa) |
| | UBE2V1 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | LRRC31 | Leucine rich repeat containing 31. (562 aa) |
| | S100B | Protein S100; Belongs to the S-100 family. (93 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (747 aa) |
| | TIRAP | TIR domain containing adaptor protein. (234 aa) |
| | TICAM2 | TIR domain-containing protein. (238 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (621 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (811 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (381 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1369 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | GSDMD | Gasdermin D. (485 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (1049 aa) |
| | ATF1 | Activating transcription factor 1. (310 aa) |
| | LY86 | Lymphocyte antigen 86. (159 aa) |
| | ECSIT | ECSIT signalling integrator. (434 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1013 aa) |
| | LY96 | Lymphocyte antigen 96. (173 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (326 aa) |
| | NKIRAS2 | NFKB inhibitor interacting Ras like 2. (191 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | IRF3 | Interferon regulatory factor 3. (426 aa) |
| | RPS6KA4 | Ribosomal protein S6 kinase. (771 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | SFTPA1 | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (265 aa) |
| | CTSK | Cathepsin K; Belongs to the peptidase C1 family. (329 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | F7CGT3_HORSE | Uncharacterized protein. (3216 aa) |
| | FNBP4 | Formin binding protein 4. (1021 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (282 aa) |
| | GSDMA | Gasdermin A. (446 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | TLR10 | Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (403 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa) |
| | GSDME | Gasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. (497 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa) |
| | F6XH74_HORSE | Uncharacterized protein. (215 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (698 aa) |
| | F6S6S0_HORSE | Uncharacterized protein. (212 aa) |
| | LOC100069988 | TIR domain-containing protein. (949 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (411 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (464 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | LOC100072493 | TIR domain-containing protein. (976 aa) |
| | SFTPD | Surfactant protein D. (375 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (488 aa) |
| | UNC93B1 | Unc-93 homolog B1, TLR signaling regulator. (571 aa) |
| | RBSN | Rabenosyn, RAB effector. (781 aa) |
| | CNPY4 | Canopy FGF signaling regulator 4. (244 aa) |
| | APP | Amyloid beta precursor protein. (811 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | LRRC14 | Leucine rich repeat containing 14. (493 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (332 aa) |
| | LOC100146191 | Uncharacterized protein. (581 aa) |
| | S100A1 | Protein S100; Belongs to the S-100 family. (94 aa) |
| | LOC100066313 | C-type lectin domain-containing protein. (249 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (554 aa) |
| | NFKBIA | NFKB inhibitor alpha. (543 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (992 aa) |
| | GSDMB | Gasdermin B. (415 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (799 aa) |
| | N4BP1 | NEDD4 binding protein 1. (897 aa) |
| | BPIFC | BPI fold containing family C. (507 aa) |
| | DUSP7 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4. (531 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | ENSECAP00000023797 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (105 aa) |
| | TANK | TRAF family member associated NFKB activator. (426 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (780 aa) |
| | TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa) |
| | LOC102148739 | NACHT domain-containing protein. (1069 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (971 aa) |
| | TLR1 | Toll-like receptor. (756 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (892 aa) |
| | CTSV | Cathepsin V; Belongs to the peptidase C1 family. (394 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa) |
| | UBE2D1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1468 aa) |
| | BPI | Bactericidal permeability increasing protein. (588 aa) |
| | HSP90B1 | Heat shock protein 90 beta family member 1. (823 aa) |
| | ATF2 | Activating transcription factor 2. (512 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (770 aa) |
| | LOC111772122 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1672 aa) |
| | CTSB | Cathepsin B; Belongs to the peptidase C1 family. (384 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa) |
| | LOC111771935 | Toll-like receptor 4. (843 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (697 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (1024 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (446 aa) |
| | ENSECAP00000035168 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa) |
| | UBC-2 | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (354 aa) |
| | ENSECAP00000036381 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (448 aa) |
| | APOB | Apolipoprotein B. (4423 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | KHNYN | KH and NYN domain containing. (666 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (363 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (630 aa) |
| | PTPN4 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (422 aa) |
| | ENSECAP00000041260 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa) |
| | ENSECAP00000041329 | Uncharacterized protein. (361 aa) |
| | PELI3 | Pellino E3 ubiquitin protein ligase family member 3. (521 aa) |
| | CD14 | CD14 molecule. (369 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (993 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (967 aa) |
| | LOC100056167 | WRNPLPNID domain-containing protein. (1089 aa) |
| | CTSL | Cathepsin L; Belongs to the peptidase C1 family. (358 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (403 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (783 aa) |
| | LOC100061631 | EF-hand domain-containing protein; Belongs to the S-100 family. (160 aa) |
| | ENSECAP00000044533 | Ubiquitin-like domain-containing protein. (180 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (805 aa) |
| | ELK1 | ETS transcription factor ELK1. (432 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | S100A12 | Protein S100; Belongs to the S-100 family. (114 aa) |
| | UNC93A | Unc-93 homolog A. (459 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (513 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1868 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1225 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa) |
| | UBE2D3 | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (592 aa) |
| | LRRC71 | Leucine rich repeat containing 71. (561 aa) |
| | SARM1 | Sterile alpha and TIR motif containing 1. (877 aa) |
| | IRF7 | Interferon regulatory factor 7. (536 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa) |
| | NFKBIB | NFKB inhibitor beta. (371 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (666 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | KXD1 | KxDL motif containing 1. (194 aa) |
| | FGG | Fibrinogen gamma chain. (460 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa) |
