STRINGSTRING
LOC100072641 LOC100072641 NRAS NRAS GRB7 GRB7 THBS3 THBS3 SRC SRC ERAS ERAS RASA1 RASA1 HRAS HRAS STAT6 STAT6 THBS1 THBS1 GRB2 GRB2 CRK CRK COL5A2 COL5A2 SOS1 SOS1 BCAR1 BCAR1 LOC100051785 LOC100051785 COL2A1 COL2A1 PLAT PLAT CASS4 CASS4 PCSK4 PCSK4 NEDD9 NEDD9 RAPGEF1 RAPGEF1 PDGFRA PDGFRA PDGFA PDGFA STAT5A STAT5A ENSECAP00000039029 ENSECAP00000039029 EFS EFS FNDC3A FNDC3A STAT3 STAT3 STAT5B STAT5B PLG PLG STAT1 STAT1 PTPN12 PTPN12 NCK2 NCK2 CRKL CRKL PDGFD PDGFD CSDE1 CSDE1 PDGFB PDGFB COL6A1 COL6A1 FNDC3B FNDC3B PIK3R2 PIK3R2 PDGFRB PDGFRB COL3A1 COL3A1 PTPN11 PTPN11 PIK3CB PIK3CB COL9A3 COL9A3 LOC100146191 LOC100146191 THBS2 THBS2 PLCG1 PLCG1 PIK3R1 PIK3R1 FURIN FURIN THBS4 THBS4 PDGFC PDGFC KRAS KRAS SPP1 SPP1 PIK3CA PIK3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100072641Uncharacterized protein. (1466 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB7Growth factor receptor bound protein 7. (532 aa)
THBS3Thrombospondin 3. (956 aa)
SRCTyrosine-protein kinase. (551 aa)
ERASES cell expressed Ras. (233 aa)
RASA1RAS p21 protein activator 1. (1041 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
THBS1Thrombospondin 1. (1170 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
LOC100051785Uncharacterized protein. (188 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
PLATPlasminogen activator, tissue type. (615 aa)
CASS4Cas scaffold protein family member 4. (975 aa)
PCSK4Uncharacterized protein. (810 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1465 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
ENSECAP00000039029Uncharacterized protein. (188 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
PLGPlasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] (817 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
PTPN12Protein tyrosine phosphatase non-receptor type 12. (786 aa)
NCK2Cytoplasmic protein. (380 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PDGFDPlatelet derived growth factor D. (566 aa)
CSDE1Cold shock domain containing E1. (820 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
COL6A1Collagen type VI alpha 1 chain. (1027 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3R2Uncharacterized protein. (479 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
COL9A3Collagen type IX alpha 3 chain. (682 aa)
LOC100146191Uncharacterized protein. (581 aa)
THBS2Thrombospondin 2. (1172 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (793 aa)
THBS4Thrombospondin 4. (961 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (368 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SPP1Secreted phosphoprotein 1. (313 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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