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SEC11A SEC11A GCG GCG ENSECAP00000039928 ENSECAP00000039928 LEP LEP IGF1 IGF1 FAP FAP SEC11C SEC11C PLA2G7 PLA2G7 GHRL GHRL INS INS SPCS1 SPCS1 PCSK1 PCSK1 SPCS3 SPCS3 GH1 GH1 SPCS2 SPCS2 MBOAT4 MBOAT4 BCHE BCHE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEC11ASignal peptidase complex catalytic subunit SEC11. (183 aa)
GCGGlucagon. (232 aa)
ENSECAP00000039928Uncharacterized protein. (183 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (788 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (216 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (512 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SPCS1Signal peptidase complex subunit 1. (169 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (754 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa)
SPCS2Signal peptidase complex subunit 2. (226 aa)
MBOAT4Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (435 aa)
BCHECholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). (681 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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