STRINGSTRING
CBL CBL SHC1 SHC1 GRB2 GRB2 PPP2CB PPP2CB SRC SRC NRAS NRAS MAPK3 MAPK3 PIK3CA PIK3CA LOC100072641 LOC100072641 FGF9 FGF9 RPS27A RPS27A KRAS KRAS PIK3R1 PIK3R1 UBA52 UBA52 FGF1 FGF1 FGF23 FGF23 LOC100146191 LOC100146191 PTPN11 PTPN11 FNDC3B FNDC3B CSDE1 CSDE1 MKNK2 MKNK2 BRAF BRAF GALNT3 GALNT3 GAB1 GAB1 UBC-2 UBC-2 FNDC3A FNDC3A FRS2 FRS2 ENSECAP00000039029 ENSECAP00000039029 ENSECAP00000044533 ENSECAP00000044533 MKNK1 MKNK1 MAPK1 MAPK1 LOC100051785 LOC100051785 SOS1 SOS1 FGFR3 FGFR3 HRAS HRAS SPRY2 SPRY2 UBC UBC ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBLCbl proto-oncogene. (914 aa)
SHC1SHC adaptor protein 1. (584 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SRCTyrosine-protein kinase. (551 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100072641Uncharacterized protein. (1466 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RPS27ARibosomal protein S27a. (156 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
LOC100146191Uncharacterized protein. (581 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
CSDE1Cold shock domain containing E1. (820 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (463 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
GAB1GRB2 associated binding protein 1. (771 aa)
UBC-2Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
FRS2Fibroblast growth factor receptor substrate 2. (515 aa)
ENSECAP00000039029Uncharacterized protein. (188 aa)
ENSECAP00000044533Ubiquitin-like domain-containing protein. (180 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (454 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
LOC100051785Uncharacterized protein. (188 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
UBCUbiquitin B. (305 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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