(49 nodes) p53-Independent DNA Damage Response network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMA1	Proteasome subunit alpha type. (269 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	PSMB1	Proteasome subunit beta 1. (406 aa)
	PSMA6	Proteasome subunit alpha type. (251 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (423 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (433 aa)
	CDC25A	Cell division cycle 25A. (524 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (531 aa)
	PSME3	Proteasome activator subunit 3. (265 aa)
	PSMF1	Proteasome inhibitor subunit 1. (289 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (526 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
	PSME4	Proteasome activator subunit 4. (1864 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	UBC-2	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa)
	PSMD4	VWFA domain-containing protein. (380 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (394 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	ENSECAP00000044533	Ubiquitin-like domain-containing protein. (180 aa)
	KXD1	KxDL motif containing 1. (194 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (441 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (270 aa)
	UBC	Ubiquitin B. (305 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
	PSMB11	Proteasome subunit beta. (299 aa)
	CHEK2	Checkpoint kinase 2. (544 aa)
	PSMB4	Proteasome subunit beta 4. (309 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (534 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	F6PQ40_HORSE	Proteasome subunit alpha type. (214 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	PSMD5	Proteasome 26S subunit, non-ATPase 5. (505 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (422 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	PSMB9	Proteasome subunit beta 9. (300 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSME2	Proteasome activator subunit 2. (239 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	PSMD9	Proteasome 26S subunit, non-ATPase 9. (224 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (324 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25A	CHEK2	ENSECAP00000027183	ENSECAP00000004610	Cell division cycle 25A.	Checkpoint kinase 2.	0.915
CDC25A	PSMC1	ENSECAP00000027183	ENSECAP00000002532	Cell division cycle 25A.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.443
CDC25A	RPS27A	ENSECAP00000027183	ENSECAP00000016396	Cell division cycle 25A.	Ribosomal protein S27a.	0.428
CHEK2	CDC25A	ENSECAP00000004610	ENSECAP00000027183	Checkpoint kinase 2.	Cell division cycle 25A.	0.915
ENSECAP00000044533	F6PQ40_HORSE	ENSECAP00000044533	ENSECAP00000010484	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.732
ENSECAP00000044533	KXD1	ENSECAP00000044533	ENSECAP00000049049	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.570
ENSECAP00000044533	PSMA1	ENSECAP00000044533	ENSECAP00000054297	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.732
ENSECAP00000044533	PSMA2	ENSECAP00000044533	ENSECAP00000018225	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.854
ENSECAP00000044533	PSMA3	ENSECAP00000044533	ENSECAP00000009546	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.853
ENSECAP00000044533	PSMA4	ENSECAP00000044533	ENSECAP00000007717	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.866
ENSECAP00000044533	PSMA5	ENSECAP00000044533	ENSECAP00000009883	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.833
ENSECAP00000044533	PSMA6	ENSECAP00000044533	ENSECAP00000019847	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.866
ENSECAP00000044533	PSMA7	ENSECAP00000044533	ENSECAP00000035117	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.713
ENSECAP00000044533	PSMA8	ENSECAP00000044533	ENSECAP00000010901	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.713
ENSECAP00000044533	PSMB1	ENSECAP00000044533	ENSECAP00000019171	Ubiquitin-like domain-containing protein.	Proteasome subunit beta 1.	0.844
ENSECAP00000044533	PSMB10	ENSECAP00000044533	ENSECAP00000010204	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.724
ENSECAP00000044533	PSMB11	ENSECAP00000044533	ENSECAP00000002806	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.675
ENSECAP00000044533	PSMB2	ENSECAP00000044533	ENSECAP00000019124	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.851
ENSECAP00000044533	PSMB4	ENSECAP00000044533	ENSECAP00000005144	Ubiquitin-like domain-containing protein.	Proteasome subunit beta 4.	0.850
ENSECAP00000044533	PSMB5	ENSECAP00000044533	ENSECAP00000014747	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.698