STRINGSTRING
IRAK1 IRAK1 ARHGEF10 ARHGEF10 TAB3 TAB3 UBE2D3 UBE2D3 ARHGEF25 ARHGEF25 ARHGEF12 ARHGEF12 SOS2 SOS2 TRAF1 TRAF1 ARHGEF7 ARHGEF7 PRDM4 PRDM4 ARHGEF16 ARHGEF16 FGD3 FGD3 PPOX PPOX FASLG FASLG OMG OMG USP4 USP4 ULK1 ULK1 SMPD2 SMPD2 MADD MADD GNA13 GNA13 NGFR NGFR TAB2 TAB2 LOC111768857 LOC111768857 RPS27A RPS27A SPPL2C SPPL2C CLIP4 CLIP4 SESTD1 SESTD1 RBCK1 RBCK1 KXD1 KXD1 PLEKHG5 PLEKHG5 LINGO2 LINGO2 APH1B APH1B MAP3K7 MAP3K7 BCL2L11 BCL2L11 MCF2 MCF2 CYLD CYLD PSEN2 PSEN2 SOS1 SOS1 VAV2 VAV2 TNFRSF1A TNFRSF1A BIRC2 BIRC2 LINGO1 LINGO1 CASP8 CASP8 SPATA2 SPATA2 ARHGEF10L ARHGEF10L PSENEN PSENEN WDR31 WDR31 OPTN OPTN TMEM198 TMEM198 UBE2D4 UBE2D4 AATF AATF ARHGEF17 ARHGEF17 MCF2L2 MCF2L2 CLIP3 CLIP3 BIRC7 BIRC7 TRIO TRIO ARHGDIA ARHGDIA UBA52 UBA52 IKBKG IKBKG SQSTM1 SQSTM1 TBK1 TBK1 TIAM1 TIAM1 TRAF6 TRAF6 FADD FADD NET1 NET1 CFLAR CFLAR ARHGEF5 ARHGEF5 MAPKAPK2 MAPKAPK2 CASP3 CASP3 RACK1 RACK1 ARHGEF11 ARHGEF11 NFKBIA NFKBIA TGM3 TGM3 CASP10 CASP10 F6SDY4_HORSE F6SDY4_HORSE TNFRSF10B TNFRSF10B ITGB3BP ITGB3BP UBE2D2 UBE2D2 LOC111768857-2 LOC111768857-2 OTUD1 OTUD1 LOC102150834 LOC102150834 ARHGEF19 ARHGEF19 XIAP XIAP SPPL2A SPPL2A IKBKE IKBKE ABR ABR ARHGEF1 ARHGEF1 PRKCI PRKCI ARHGEF37 ARHGEF37 LOC100067370 LOC100067370 MCF2L MCF2L ARHGEF9 ARHGEF9 TAB1 TAB1 UBE2D1 UBE2D1 TIAM2 TIAM2 BEX3 BEX3 ULK2 ULK2 IKBKB IKBKB CASP2 CASP2 APH1A APH1A ENSECAP00000031719 ENSECAP00000031719 OTULIN OTULIN ARHGEF33 ARHGEF33 RIPK2 RIPK2 ADAM17 ADAM17 ARHGEF26 ARHGEF26 AKAP13 AKAP13 UBC-2 UBC-2 TGM6 TGM6 CHUK CHUK ARHGEF15 ARHGEF15 ECT2L ECT2L LOC111771929 LOC111771929 OTULINL OTULINL KALRN KALRN ECT2 ECT2 ARHGEF18 ARHGEF18 NCSTN NCSTN LOC111776006 LOC111776006 TNFSF10 TNFSF10 USP2 USP2 PLEKHG2 PLEKHG2 FGD4 FGD4 ARHGEF39 ARHGEF39 YWHAE YWHAE TNFAIP3 TNFAIP3 RIPK1 RIPK1 BAG4 BAG4 NGF NGF LOC100058940 LOC100058940 NFATC4 NFATC4 ARHGEF38 ARHGEF38 MAG MAG FGD1 FGD1 SMPD3 SMPD3 MAP3K20 MAP3K20 SHARPIN SHARPIN NSMAF NSMAF TNF TNF MYD88 MYD88 LOC100071666 LOC100071666 NAIP NAIP UBC UBC TAX1BP1 TAX1BP1 PSEN1 PSEN1 RTN4R RTN4R NGEF NGEF SMPD5 SMPD5 RTN4 RTN4 ARHGEF6 ARHGEF6 TRAF2 TRAF2 ITSN1 ITSN1 TRADD TRADD FAS FAS RELA RELA FGD2 FGD2 F7CNV6_HORSE F7CNV6_HORSE ARHGEF2 ARHGEF2 STUB1 STUB1 BAD BAD SPPL2B SPPL2B PREX1 PREX1 MIB2 MIB2 ARHGEF3 ARHGEF3 NFKB1 NFKB1 VAV1 VAV1 VAV3 VAV3 ENSECAP00000044533 ENSECAP00000044533
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1408 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
ARHGEF25Rho guanine nucleotide exchange factor 25. (619 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
TRAF1TNF receptor-associated factor. (415 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (893 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (749 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (730 aa)
PPOXUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa)
OMGOligodendrocyte myelin glycoprotein. (443 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (963 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1059 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
MADDMAP kinase activating death domain. (1647 aa)
GNA13G protein subunit alpha 13. (377 aa)
NGFRNerve growth factor receptor. (435 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LOC111768857Uncharacterized protein. (642 aa)
RPS27ARibosomal protein S27a. (156 aa)
SPPL2CSignal peptide peptidase like 2C. (682 aa)
CLIP4CAP-Gly domain containing linker protein family member 4. (748 aa)
SESTD1SEC14 and spectrin domain containing 1. (718 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (535 aa)
KXD1KxDL motif containing 1. (194 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1080 aa)
LINGO2Uncharacterized protein. (606 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (524 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)
BCL2L11BCL2 like 11. (289 aa)
MCF2MCF.2 cell line derived transforming sequence. (1177 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (619 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
TNFRSF1ATNF receptor superfamily member 1A. (475 aa)
BIRC2Baculoviral IAP repeat containing 3. (604 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (464 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1280 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
WDR31WD repeat domain 31. (537 aa)
OPTNOptineurin. (574 aa)
TMEM198Transmembrane protein 198. (360 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
AATFApoptosis antagonizing transcription factor. (566 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (2063 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1063 aa)
CLIP3CAP-Gly domain containing linker protein 3. (622 aa)
BIRC7Baculoviral IAP repeat containing 7. (282 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3107 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (204 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
SQSTM1Sequestosome 1. (440 aa)
TBK1TANK binding kinase 1. (729 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
NET1Neuroepithelial cell transforming 1. (596 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (510 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1687 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1560 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
TGM3Transglutaminase 3. (694 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (478 aa)
F6SDY4_HORSETNFR-Cys domain-containing protein. (296 aa)
TNFRSF10BUncharacterized protein. (423 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (192 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
LOC111768857-2Uncharacterized protein. (1341 aa)
OTUD1OTU deubiquitinase 1. (485 aa)
LOC102150834Uncharacterized protein. (430 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (989 aa)
XIAPX-linked inhibitor of apoptosis. (494 aa)
SPPL2ASignal peptide peptidase like 2A. (540 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
ABRABR activator of RhoGEF and GTPase. (1191 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1040 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (655 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (693 aa)
LOC100067370Uncharacterized protein. (461 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1185 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (1167 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
UBE2D1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1708 aa)
BEX3Brain expressed X-linked 3. (255 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1059 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (274 aa)
ENSECAP00000031719Uncharacterized protein. (438 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (350 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (889 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
ADAM17ADAM metallopeptidase domain 17. (891 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (797 aa)
AKAP13A-kinase anchoring protein 13. (2905 aa)
UBC-2Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa)
TGM6Transglutaminase 6. (708 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (852 aa)
ECT2LEpithelial cell transforming 2 like. (959 aa)
LOC111771929Rho guanine nucleotide exchange factor 4. (483 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (366 aa)
KALRNKalirin RhoGEF kinase. (2987 aa)
ECT2Epithelial cell transforming 2. (1042 aa)
ARHGEF18Uncharacterized protein. (1423 aa)
NCSTNNicastrin. (709 aa)
LOC111776006Uncharacterized protein. (380 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (289 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (665 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1423 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (940 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (312 aa)
TNFAIP3TNF alpha induced protein 3. (794 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
LOC100058940DUF4203 domain-containing protein. (350 aa)
NFATC4Nuclear factor of activated T cells 4. (932 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (778 aa)
MAGMyelin associated glycoprotein. (626 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (960 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
MAP3K20Uncharacterized protein. (850 aa)
SHARPINSHANK associated RH domain interactor. (384 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (920 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
LOC100071666RanBP2-type domain-containing protein. (413 aa)
NAIPNLR family apoptosis inhibitory protein. (1402 aa)
UBCUbiquitin B. (305 aa)
TAX1BP1Tax1 binding protein 1. (816 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
RTN4RReticulon 4 receptor. (473 aa)
NGEFNeuronal guanine nucleotide exchange factor. (787 aa)
SMPD5Endo/exonuclease/phosphatase domain-containing protein. (477 aa)
RTN4Reticulon. (1196 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
ITSN1Intersectin 1. (1745 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
FASFas cell surface death receptor. (365 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (657 aa)
F7CNV6_HORSEUncharacterized protein. (1071 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1176 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SPPL2BSignal peptide peptidase like 2B. (565 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1757 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (957 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (634 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
VAV1Vav guanine nucleotide exchange factor 1. (918 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
ENSECAP00000044533Ubiquitin-like domain-containing protein. (180 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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