(87 nodes) Signaling by Insulin receptor network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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	LOC100069009	Uncharacterized protein. (571 aa)
	TRIB3	Tribbles pseudokinase 3. (353 aa)
	SPEM2	SPEM family member 2. (488 aa)
	IRS2	Insulin receptor substrate 2. (1401 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	IRS1	Insulin receptor substrate 1. (1239 aa)
	KL	Klotho. (1011 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	LIM2	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	ATP6V1C2	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (647 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	ATP6V1E2	ATPase H+ transporting V1 subunit E2. (226 aa)
	LOC100064677	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	TLR9	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	ATP6V0E2	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (467 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	ATP6V0D2	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	FGF5	Fibroblast growth factor 5. (280 aa)
	ATP6V0D1	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
	SPEM1	Spermatid maturation 1. (314 aa)
	ATP6V1D	V-type proton ATPase subunit D-like protein. (247 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	CNST	Consortin, connexin sorting protein. (725 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	NRDC	Nardilysin convertase. (1247 aa)
	LOC100146191	Uncharacterized protein. (581 aa)
	ATP6V1B1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
	KLB	Klotho beta. (1045 aa)
	ATP6V1G3	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	ATP6V0B	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (999 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
	PDE3B	Phosphodiesterase. (1125 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	PIK3R2	Uncharacterized protein. (479 aa)
	PTPN1	Protein tyrosine phosphatase non-receptor type 1. (493 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
	FLT3LG	Fms related tyrosine kinase 3 ligand. (241 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1468 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
	THEM4	Thioesterase superfamily member 4. (253 aa)
	IDE	Insulin degrading enzyme. (1212 aa)
	GAB1	GRB2 associated binding protein 1. (771 aa)
	LOC102147639	4HBT domain-containing protein. (246 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
	GAB2	GRB2 associated binding protein 2. (708 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1923 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (618 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (515 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (536 aa)
	GRB10	Growth factor receptor bound protein 10. (594 aa)
	ATP6AP1L	ATPase H+ transporting accessory protein 1 like. (344 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (585 aa)
	ATP6V1G1	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	ATP6V1F	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	FGFR1	Fibroblast growth factor receptor. (877 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
	ATP6V1E1	ATPase H+ transporting V1 subunit E1. (279 aa)
	ATP6V1G2	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
	FGFR2	Fibroblast growth factor receptor. (887 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
	FGFR4	Fibroblast growth factor receptor. (855 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
	FGFR3	Fibroblast growth factor receptor. (804 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	ATP6AP1L	ENSECAP00000012091	ENSECAP00000044155	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting accessory protein 1 like.	0.549
ATP6AP1	ATP6V0A1	ENSECAP00000012091	ENSECAP00000014931	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.999
ATP6AP1	ATP6V0A2	ENSECAP00000012091	ENSECAP00000022132	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.988
ATP6AP1	ATP6V0A4	ENSECAP00000012091	ENSECAP00000015255	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.989
ATP6AP1	ATP6V0B	ENSECAP00000012091	ENSECAP00000021815	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.999
ATP6AP1	ATP6V0C	ENSECAP00000012091	ENSECAP00000022992	ATPase H+ transporting accessory protein 1.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.998
ATP6AP1	ATP6V0D1	ENSECAP00000012091	ENSECAP00000013371	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.999
ATP6AP1	ATP6V0D2	ENSECAP00000012091	ENSECAP00000013267	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.994
ATP6AP1	ATP6V0E2	ENSECAP00000012091	ENSECAP00000012085	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.986
ATP6AP1	ATP6V1A	ENSECAP00000012091	ENSECAP00000037709	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit A.	0.998
ATP6AP1	ATP6V1B1	ENSECAP00000012091	ENSECAP00000020289	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.986
ATP6AP1	ATP6V1B2	ENSECAP00000012091	ENSECAP00000014612	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.989
ATP6AP1	ATP6V1C1	ENSECAP00000012091	ENSECAP00000027959	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.998
ATP6AP1	ATP6V1C2	ENSECAP00000012091	ENSECAP00000008717	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.968
ATP6AP1	ATP6V1D	ENSECAP00000012091	ENSECAP00000015103	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit D-like protein.	0.998
ATP6AP1	ATP6V1E1	ENSECAP00000012091	ENSECAP00000049079	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit E1.	0.998
ATP6AP1	ATP6V1E2	ENSECAP00000012091	ENSECAP00000011382	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit E2.	0.937
ATP6AP1	ATP6V1F	ENSECAP00000012091	ENSECAP00000045027	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.997
ATP6AP1	ATP6V1G1	ENSECAP00000012091	ENSECAP00000044797	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.978
ATP6AP1	ATP6V1G2	ENSECAP00000012091	ENSECAP00000049273	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.957