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COQ9 COQ9 COQ6 COQ6 COQ2 COQ2 ITPRIPL2 ITPRIPL2 IDH1 IDH1 ITPRIP ITPRIP CALM1 CALM1 CALML3 CALML3 COQ5 COQ5 GCH1 GCH1 PTS PTS COQ3 COQ3 SPR SPR COQ7 COQ7 PDSS1 PDSS1 PRKG2 PRKG2 NOS3 NOS3 PDSS2 PDSS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COQ9Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (336 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (547 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (391 aa)
ITPRIPL2ITPRIP like 2. (518 aa)
IDH1Isocitrate dehydrogenase (NADP(+)) 1, cytosolic. (641 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (566 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (353 aa)
GCH1GTP cyclohydrolase 1. (415 aa)
PTS6-pyruvoyl tetrahydrobiopterin synthase. (144 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (370 aa)
SPRSepiapterin reductase. (267 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
PDSS1Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (408 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
PDSS2Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (410 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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