STRINGSTRING
SHC1 SHC1 PIK3CD PIK3CD EPOR EPOR GRB2 GRB2 JAK2 JAK2 PIK3CA PIK3CA VAV1 VAV1 PIK3CG PIK3CG PIK3R1 PIK3R1 PIK3CB PIK3CB CRKL CRKL GAB1 GAB1 EPO EPO LYN LYN RAPGEF1 RAPGEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHC1SHC adaptor protein 1. (584 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VAV1Vav guanine nucleotide exchange factor 1. (918 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GAB1GRB2 associated binding protein 1. (771 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
LYNTyrosine-protein kinase. (533 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1465 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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