STRINGSTRING
CRK CRK PIK3CA PIK3CA VAV1 VAV1 RPS27A RPS27A PIK3R1 PIK3R1 UBA52 UBA52 YES1 YES1 PIK3CB PIK3CB PIK3R2 PIK3R2 RAPGEF1 RAPGEF1 ENSECAP00000044533 ENSECAP00000044533 LYN LYN SYK SYK UBC-2 UBC-2 LOC100052122 LOC100052122 CRKL CRKL UBC UBC CBL CBL PIK3CD PIK3CD GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VAV1Vav guanine nucleotide exchange factor 1. (918 aa)
RPS27ARibosomal protein S27a. (156 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
YES1Tyrosine-protein kinase. (583 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R2Uncharacterized protein. (479 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1465 aa)
ENSECAP00000044533Ubiquitin-like domain-containing protein. (180 aa)
LYNTyrosine-protein kinase. (533 aa)
SYKTyrosine-protein kinase. (716 aa)
UBC-2Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa)
LOC100052122Uncharacterized protein. (461 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
UBCUbiquitin B. (305 aa)
CBLCbl proto-oncogene. (914 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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