22 items (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC111767791	CD14 molecule. (376 aa)
	UBC	Ubiquitin B. (305 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (698 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	TICAM2	TIR domain-containing protein. (238 aa)
	LY96	Lymphocyte antigen 96. (173 aa)
	IRF3	Interferon regulatory factor 3. (426 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	LOC100146191	Uncharacterized protein. (581 aa)
	TANK	TRAF family member associated NFKB activator. (426 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
	LOC111772122	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)
	UBC-2	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa)
	CD14	CD14 molecule. (369 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	ENSECAP00000044533	Ubiquitin-like domain-containing protein. (180 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (877 aa)
	IRF7	Interferon regulatory factor 7. (536 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	LOC111767791	ENSECAP00000042386	ENSECAP00000001239	CD14 molecule.	CD14 molecule.	0.655
CD14	LOC111771935	ENSECAP00000042386	ENSECAP00000033420	CD14 molecule.	Toll-like receptor 4.	0.717
CD14	LOC111772122	ENSECAP00000042386	ENSECAP00000031530	CD14 molecule.	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	0.543
CD14	LY96	ENSECAP00000042386	ENSECAP00000015094	CD14 molecule.	Lymphocyte antigen 96.	0.854
CD14	TLR4	ENSECAP00000042386	ENSECAP00000008292	CD14 molecule.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.723
ENSECAP00000044533	IKBKE	ENSECAP00000044533	ENSECAP00000024782	Ubiquitin-like domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.434
ENSECAP00000044533	TBK1	ENSECAP00000044533	ENSECAP00000018587	Ubiquitin-like domain-containing protein.	TANK binding kinase 1.	0.464
ENSECAP00000044533	TRAF3	ENSECAP00000044533	ENSECAP00000043236	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.608
ENSECAP00000044533	TRAF5	ENSECAP00000044533	ENSECAP00000005414	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.577
ENSECAP00000044533	UBA52	ENSECAP00000044533	ENSECAP00000018080	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.983
ENSECAP00000044533	UBC	ENSECAP00000044533	ENSECAP00000002343	Ubiquitin-like domain-containing protein.	Ubiquitin B.	0.781
ENSECAP00000044533	UBC-2	ENSECAP00000044533	ENSECAP00000035675	Ubiquitin-like domain-containing protein.	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...]	0.781
IKBKE	ENSECAP00000044533	ENSECAP00000024782	ENSECAP00000044533	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Ubiquitin-like domain-containing protein.	0.434
IKBKE	IRF3	ENSECAP00000024782	ENSECAP00000015946	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Interferon regulatory factor 3.	0.987
IKBKE	IRF7	ENSECAP00000024782	ENSECAP00000047371	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Interferon regulatory factor 7.	0.563
IKBKE	LOC111771935	ENSECAP00000024782	ENSECAP00000033420	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Toll-like receptor 4.	0.520
IKBKE	LY96	ENSECAP00000024782	ENSECAP00000015094	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Lymphocyte antigen 96.	0.545
IKBKE	RPS27A	ENSECAP00000024782	ENSECAP00000016396	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Ribosomal protein S27a.	0.482
IKBKE	TANK	ENSECAP00000024782	ENSECAP00000024309	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TRAF family member associated NFKB activator.	0.985
IKBKE	TBK1	ENSECAP00000024782	ENSECAP00000018587	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TANK binding kinase 1.	0.997