22 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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gene fusions

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Your Input:
	CD14	CD14 molecule. (369 aa)
	MAP3K20	Uncharacterized protein. (850 aa)
	LOC111767791	CD14 molecule. (376 aa)
	UBC	Ubiquitin B. (305 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (698 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	TICAM2	TIR domain-containing protein. (238 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (621 aa)
	LY96	Lymphocyte antigen 96. (173 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
	LOC111772122	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)
	UBC-2	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (305 aa)
	ENSECAP00000044533	Ubiquitin-like domain-containing protein. (180 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (877 aa)
	KXD1	KxDL motif containing 1. (194 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	LOC111767791	ENSECAP00000042386	ENSECAP00000001239	CD14 molecule.	CD14 molecule.	0.655
CD14	LOC111771935	ENSECAP00000042386	ENSECAP00000033420	CD14 molecule.	Toll-like receptor 4.	0.717
CD14	LOC111772122	ENSECAP00000042386	ENSECAP00000031530	CD14 molecule.	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	0.543
CD14	LY96	ENSECAP00000042386	ENSECAP00000015094	CD14 molecule.	Lymphocyte antigen 96.	0.854
CD14	TLR4	ENSECAP00000042386	ENSECAP00000008292	CD14 molecule.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.723
ENSECAP00000044533	IRAK2	ENSECAP00000044533	ENSECAP00000010808	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 2.	0.417
ENSECAP00000044533	KXD1	ENSECAP00000044533	ENSECAP00000049049	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.570
ENSECAP00000044533	MAP3K20	ENSECAP00000044533	ENSECAP00000000450	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.437
ENSECAP00000044533	MAP3K7	ENSECAP00000044533	ENSECAP00000051563	Ubiquitin-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.452
ENSECAP00000044533	TAB1	ENSECAP00000044533	ENSECAP00000028874	Ubiquitin-like domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.424
ENSECAP00000044533	TAB2	ENSECAP00000044533	ENSECAP00000015601	Ubiquitin-like domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.769
ENSECAP00000044533	TAB3	ENSECAP00000044533	ENSECAP00000045167	Ubiquitin-like domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.705
ENSECAP00000044533	TRAF6	ENSECAP00000044533	ENSECAP00000018618	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.885
ENSECAP00000044533	UBA52	ENSECAP00000044533	ENSECAP00000018080	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.983
ENSECAP00000044533	UBC	ENSECAP00000044533	ENSECAP00000002343	Ubiquitin-like domain-containing protein.	Ubiquitin B.	0.781
ENSECAP00000044533	UBC-2	ENSECAP00000044533	ENSECAP00000035675	Ubiquitin-like domain-containing protein.	Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...]	0.781
IRAK2	ENSECAP00000044533	ENSECAP00000010808	ENSECAP00000044533	Interleukin 1 receptor associated kinase 2.	Ubiquitin-like domain-containing protein.	0.417
IRAK2	LOC111771935	ENSECAP00000010808	ENSECAP00000033420	Interleukin 1 receptor associated kinase 2.	Toll-like receptor 4.	0.706
IRAK2	LY96	ENSECAP00000010808	ENSECAP00000015094	Interleukin 1 receptor associated kinase 2.	Lymphocyte antigen 96.	0.598
IRAK2	MAP3K20	ENSECAP00000010808	ENSECAP00000000450	Interleukin 1 receptor associated kinase 2.	Uncharacterized protein.	0.504