56 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100055504	ANK_REP_REGION domain-containing protein. (2219 aa)
	DSG1	Desmoglein 1. (397 aa)
	RBMX	RNA binding motif protein X-linked. (391 aa)
	TXNL1	Thioredoxin like 1. (303 aa)
	CCDC88A	Coiled-coil domain containing 88A. (2029 aa)
	DDX4	DEAD-box helicase 4; Belongs to the DEAD box helicase family. (728 aa)
	LEMD3	LEM domain containing 3. (913 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1520 aa)
	KTN1	Kinectin 1. (1402 aa)
	PIK3R2	Uncharacterized protein. (479 aa)
	MAPK1IP1L	Mitogen-activated protein kinase 1 interacting protein 1 like. (244 aa)
	RBM3	RNA binding motif protein 3. (156 aa)
	WDR6	WD repeat domain 6. (1186 aa)
	SEMA4G	Semaphorin 4G; Belongs to the semaphorin family. (844 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	VANGL2	Vang-like protein. (521 aa)
	RND3	Rho family GTPase 3. (244 aa)
	CPD	Carboxypeptidase D. (1385 aa)
	VANGL1	Vang-like protein. (524 aa)
	KCNRG	Potassium channel regulator. (272 aa)
	DEPDC1B	DEP domain containing 1B. (529 aa)
	NISCH	Nischarin. (1519 aa)
	CKAP4	Cytoskeleton associated protein 4. (586 aa)
	HEG1	Heart development protein with EGF like domains 1. (1365 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	KCTD10	Potassium channel tetramerization domain containing 10. (318 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (1000 aa)
	RRBP1	Ribosome binding protein 1. (1577 aa)
	PKP4	Plakophilin 4. (1206 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
	RBM39	RNA binding motif protein 39. (530 aa)
	KCTD13	Potassium channel tetramerization domain containing 13. (329 aa)
	TNFAIP1	TNF alpha induced protein 1. (316 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	UBXN11	UBX domain protein 11. (482 aa)
	CKB	Creatine kinase B; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
	EPHA2	EPH receptor A2. (975 aa)
	RBM23	RNA binding motif protein 23. (453 aa)
	SCRIB	Scribble planar cell polarity protein. (1690 aa)
	ANKRD17	Ankyrin repeat domain 17. (2607 aa)
	RASAL2	RAS protein activator like 2. (1419 aa)
	MACF1	Microtubule actin crosslinking factor 1. (7655 aa)
	CIRBP	Cold inducible RNA binding protein. (172 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1080 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (770 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (686 aa)
	FAM83B	Family with sequence similarity 83 member B. (1011 aa)
	ENSECAP00000042520	RRM domain-containing protein. (125 aa)
	PTPN13	Protein tyrosine phosphatase non-receptor type 13. (2524 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1962 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1553 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	MAP4	Microtubule-associated protein. (1106 aa)
	ENSECAP00000038991	RRM domain-containing protein. (86 aa)
	CTNND2	Catenin delta 2. (1249 aa)
	DST	Dystonin. (7632 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP21	ARHGAP5	ENSECAP00000041791	ENSECAP00000025817	Rho GTPase activating protein 21.	Rho GTPase activating protein 5.	0.449
ARHGAP21	CCDC88A	ENSECAP00000041791	ENSECAP00000032197	Rho GTPase activating protein 21.	Coiled-coil domain containing 88A.	0.435
ARHGAP21	RND3	ENSECAP00000041791	ENSECAP00000018838	Rho GTPase activating protein 21.	Rho family GTPase 3.	0.543
ARHGAP21	WDR6	ENSECAP00000041791	ENSECAP00000021398	Rho GTPase activating protein 21.	WD repeat domain 6.	0.472
ARHGAP35	ARHGAP5	ENSECAP00000040806	ENSECAP00000025817	Rho GTPase activating protein 35.	Rho GTPase activating protein 5.	0.900
ARHGAP35	PKP4	ENSECAP00000040806	ENSECAP00000012456	Rho GTPase activating protein 35.	Plakophilin 4.	0.538
ARHGAP35	RASAL2	ENSECAP00000040806	ENSECAP00000052585	Rho GTPase activating protein 35.	RAS protein activator like 2.	0.558
ARHGAP35	RND3	ENSECAP00000040806	ENSECAP00000018838	Rho GTPase activating protein 35.	Rho family GTPase 3.	0.801
ARHGAP5	ARHGAP21	ENSECAP00000025817	ENSECAP00000041791	Rho GTPase activating protein 5.	Rho GTPase activating protein 21.	0.449
ARHGAP5	ARHGAP35	ENSECAP00000025817	ENSECAP00000040806	Rho GTPase activating protein 5.	Rho GTPase activating protein 35.	0.900
ARHGAP5	DST	ENSECAP00000025817	ENSECAP00000035787	Rho GTPase activating protein 5.	Dystonin.	0.588
ARHGAP5	KCTD10	ENSECAP00000025817	ENSECAP00000017192	Rho GTPase activating protein 5.	Potassium channel tetramerization domain containing 10.	0.823
ARHGAP5	PKP4	ENSECAP00000025817	ENSECAP00000012456	Rho GTPase activating protein 5.	Plakophilin 4.	0.516
ARHGAP5	RASAL2	ENSECAP00000025817	ENSECAP00000052585	Rho GTPase activating protein 5.	RAS protein activator like 2.	0.739
ARHGAP5	RND3	ENSECAP00000025817	ENSECAP00000018838	Rho GTPase activating protein 5.	Rho family GTPase 3.	0.941
CAV1	EPHA2	ENSECAP00000040612	ENSECAP00000006952	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	EPH receptor A2.	0.485
CAV1	FLOT2	ENSECAP00000040612	ENSECAP00000010141	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.784
CAV1	RND3	ENSECAP00000040612	ENSECAP00000018838	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Rho family GTPase 3.	0.530
CAV1	ROCK1	ENSECAP00000040612	ENSECAP00000019271	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.510
CCDC88A	ARHGAP21	ENSECAP00000032197	ENSECAP00000041791	Coiled-coil domain containing 88A.	Rho GTPase activating protein 21.	0.435