STRINGSTRING
GPX3 GPX3 ITGB1 ITGB1 PDCD4 PDCD4 DICER1 DICER1 MAOA MAOA CXCL14 CXCL14 SULF2 SULF2 BMP7 BMP7 CD55 CD55 KLF13 KLF13 NRP1 NRP1 LTF LTF IGF1 IGF1 ERBB2 ERBB2 IDO1 IDO1 IL1R1 IL1R1 IL15 IL15 TXNIP TXNIP RPL19 RPL19 KLF9 KLF9 ERBB3 ERBB3 E2F1 E2F1 SST SST ERBB4 ERBB4 PAPPA PAPPA CYP26A1 CYP26A1 FBN1 FBN1 IGFBP6 IGFBP6 DKK1 DKK1 PTEN PTEN CNN1 CNN1 CEL CEL IGFBP5 IGFBP5 EGF EGF SLC1A1 SLC1A1 DUSP1 DUSP1 IFNGR1 IFNGR1 TRH TRH IHH IHH MAOB MAOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
PDCD4Programmed cell death 4. (479 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1926 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (922 aa)
CXCL14C-X-C motif chemokine ligand 14. (125 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
BMP7Bone morphogenetic protein 7. (437 aa)
CD55Uncharacterized protein. (411 aa)
KLF13Kruppel like factor 13. (291 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (715 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (434 aa)
IL1R1Interleukin 1 receptor type 1. (578 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (432 aa)
TXNIPThioredoxin interacting protein. (391 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa)
KLF9Kruppel like factor 9. (244 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
E2F1E2F transcription factor 1. (436 aa)
SSTSomatostatin. (116 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PAPPAPappalysin 1. (1627 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
FBN1Fibrillin 1. (3030 aa)
IGFBP6Insulin like growth factor binding protein 6. (237 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
PTENPhosphatase and tensin homolog. (576 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (375 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (599 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
SLC1A1Amino acid transporter. (524 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
IFNGR1Interferon gamma receptor 1. (472 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (245 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MAOBAmine oxidase. (520 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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