10 items (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	TLR6	Toll-like receptor. (859 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	TIRAP	TIR domain containing adaptor protein. (234 aa)
	TLR10	Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
	TLR1	Toll-like receptor. (756 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111771935	MYD88	ENSECAP00000033420	ENSECAP00000001633	Toll-like receptor 4.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.997
LOC111771935	TIRAP	ENSECAP00000033420	ENSECAP00000010139	Toll-like receptor 4.	TIR domain containing adaptor protein.	0.979
LOC111771935	TLR1	ENSECAP00000033420	ENSECAP00000026625	Toll-like receptor 4.	Toll-like receptor.	0.776
LOC111771935	TLR10	ENSECAP00000033420	ENSECAP00000018320	Toll-like receptor 4.	Toll like receptor 10; Belongs to the Toll-like receptor family.	0.625
LOC111771935	TLR3	ENSECAP00000033420	ENSECAP00000032318	Toll-like receptor 4.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.596
LOC111771935	TLR4	ENSECAP00000033420	ENSECAP00000008292	Toll-like receptor 4.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.824
LOC111771935	TLR5	ENSECAP00000033420	ENSECAP00000039314	Toll-like receptor 4.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.592
LOC111771935	TLR6	ENSECAP00000033420	ENSECAP00000001398	Toll-like receptor 4.	Toll-like receptor.	0.992
LOC111771935	TLR7	ENSECAP00000033420	ENSECAP00000024910	Toll-like receptor 4.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.597
MYD88	LOC111771935	ENSECAP00000001633	ENSECAP00000033420	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 4.	0.997
MYD88	TIRAP	ENSECAP00000001633	ENSECAP00000010139	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TIR domain containing adaptor protein.	0.996
MYD88	TLR1	ENSECAP00000001633	ENSECAP00000026625	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor.	0.995
MYD88	TLR10	ENSECAP00000001633	ENSECAP00000018320	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 10; Belongs to the Toll-like receptor family.	0.848
MYD88	TLR3	ENSECAP00000001633	ENSECAP00000032318	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.983
MYD88	TLR4	ENSECAP00000001633	ENSECAP00000008292	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.999
MYD88	TLR5	ENSECAP00000001633	ENSECAP00000039314	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.994
MYD88	TLR6	ENSECAP00000001633	ENSECAP00000001398	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor.	0.997
MYD88	TLR7	ENSECAP00000001633	ENSECAP00000024910	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.997
TIRAP	LOC111771935	ENSECAP00000010139	ENSECAP00000033420	TIR domain containing adaptor protein.	Toll-like receptor 4.	0.979
TIRAP	MYD88	ENSECAP00000010139	ENSECAP00000001633	TIR domain containing adaptor protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.996