(9 nodes) (2011) Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. network (Equus caballus)

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second shell of interactors

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Your Input:
	CD4	CD4 molecule. (460 aa)
	LOX	Lysyl oxidase. (481 aa)
	CD80	CD80 molecule. (305 aa)
	FOXP3	Forkhead box P3. (452 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
	MBP	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (349 aa)
	CD68	Macrosialin-like protein. (322 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD68	ENSECAP00000007248	ENSECAP00000002079	CD4 molecule.	Macrosialin-like protein.	0.816
CD4	CD80	ENSECAP00000007248	ENSECAP00000033208	CD4 molecule.	CD80 molecule.	0.943
CD4	CTLA4	ENSECAP00000007248	ENSECAP00000002814	CD4 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.954
CD4	EPO	ENSECAP00000007248	ENSECAP00000037030	CD4 molecule.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.534
CD4	FOXP3	ENSECAP00000007248	ENSECAP00000035296	CD4 molecule.	Forkhead box P3.	0.963
CD4	IL10	ENSECAP00000007248	ENSECAP00000007097	CD4 molecule.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.969
CD4	MBP	ENSECAP00000007248	ENSECAP00000048300	CD4 molecule.	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).	0.596
CD68	CD4	ENSECAP00000002079	ENSECAP00000007248	Macrosialin-like protein.	CD4 molecule.	0.816
CD68	CD80	ENSECAP00000002079	ENSECAP00000033208	Macrosialin-like protein.	CD80 molecule.	0.729
CD68	CTLA4	ENSECAP00000002079	ENSECAP00000002814	Macrosialin-like protein.	Cytotoxic T-lymphocyte associated protein 4.	0.441
CD68	FOXP3	ENSECAP00000002079	ENSECAP00000035296	Macrosialin-like protein.	Forkhead box P3.	0.710
CD68	IL10	ENSECAP00000002079	ENSECAP00000007097	Macrosialin-like protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.920
CD68	MBP	ENSECAP00000002079	ENSECAP00000048300	Macrosialin-like protein.	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).	0.691
CD80	CD4	ENSECAP00000033208	ENSECAP00000007248	CD80 molecule.	CD4 molecule.	0.943
CD80	CD68	ENSECAP00000033208	ENSECAP00000002079	CD80 molecule.	Macrosialin-like protein.	0.729
CD80	CTLA4	ENSECAP00000033208	ENSECAP00000002814	CD80 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.999
CD80	FOXP3	ENSECAP00000033208	ENSECAP00000035296	CD80 molecule.	Forkhead box P3.	0.813
CD80	IL10	ENSECAP00000033208	ENSECAP00000007097	CD80 molecule.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.896
CTLA4	CD4	ENSECAP00000002814	ENSECAP00000007248	Cytotoxic T-lymphocyte associated protein 4.	CD4 molecule.	0.954
CTLA4	CD68	ENSECAP00000002814	ENSECAP00000002079	Cytotoxic T-lymphocyte associated protein 4.	Macrosialin-like protein.	0.441