(21 nodes) (2011) Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2STAT5-mediated signalling pathway, involving negative feedback inhibition. network (Equus caballus)

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Your Input:
	STAT1	Signal transducer and activator of transcription. (749 aa)
	SOCS2	Suppressor of cytokine signaling 2. (270 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	PXDN	Peroxidasin. (1596 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	JAK1	Tyrosine-protein kinase. (1141 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (294 aa)
	JAK2	Tyrosine-protein kinase. (1131 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	SOCS3	Suppressor of cytokine signaling 3. (229 aa)
	PRL	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (234 aa)
	CISH	Cytokine inducible SH2 containing protein. (291 aa)
	PXDNL	Peroxidasin like. (1243 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	SOCS1	Suppressor of cytokine signaling 1. (222 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	IFNG	ENSECAP00000049195	ENSECAP00000030547	Cytokine inducible SH2 containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.521
CISH	IL6	ENSECAP00000049195	ENSECAP00000014219	Cytokine inducible SH2 containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.477
CISH	JAK1	ENSECAP00000049195	ENSECAP00000016857	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.464
CISH	JAK2	ENSECAP00000049195	ENSECAP00000008048	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.484
CISH	SOCS1	ENSECAP00000049195	ENSECAP00000022763	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 1.	0.685
CISH	SOCS2	ENSECAP00000049195	ENSECAP00000032807	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 2.	0.744
CISH	SOCS3	ENSECAP00000049195	ENSECAP00000001322	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 3.	0.739
CISH	STAT1	ENSECAP00000049195	ENSECAP00000032378	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.937
CISH	STAT3	ENSECAP00000049195	ENSECAP00000036035	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.948
CISH	STAT6	ENSECAP00000049195	ENSECAP00000007114	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.943
EGF	GAPDH	ENSECAP00000009190	ENSECAP00000019665	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Glyceraldehyde-3-phosphate dehydrogenase.	0.890
EGF	IFNG	ENSECAP00000009190	ENSECAP00000030547	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.638
EGF	IGF1	ENSECAP00000009190	ENSECAP00000033255	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.988
EGF	IL6	ENSECAP00000009190	ENSECAP00000014219	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.765
EGF	INS	ENSECAP00000009190	ENSECAP00000022114	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.997
EGF	INSR	ENSECAP00000009190	ENSECAP00000008032	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase receptor.	0.949
EGF	JAK1	ENSECAP00000009190	ENSECAP00000016857	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase.	0.401
EGF	JAK2	ENSECAP00000009190	ENSECAP00000008048	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase.	0.504
EGF	NGF	ENSECAP00000009190	ENSECAP00000008419	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Nerve growth factor; Belongs to the NGF-beta family.	0.766
EGF	PRL	ENSECAP00000009190	ENSECAP00000000120	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.	0.630