(27 nodes) (2011) Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	LOC100063835	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	H4C15	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (106 aa)
	LOC100630823	Histone H4. (103 aa)
	LOC100054521	Histone H4. (103 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (445 aa)
	LOC106782250	Histone H4. (103 aa)
	PXDN	Peroxidasin. (1596 aa)
	LOC100054332	Histone H4. (99 aa)
	LOC106782239	Histone H4. (103 aa)
	EGFR	Receptor protein-tyrosine kinase. (1195 aa)
	RCAN1	Regulator of calcineurin 1. (249 aa)
	CALML5	Calmodulin like 5. (149 aa)
	SDC3	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (503 aa)
	LOC100053403	Histone H4. (103 aa)
	SDC4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
	LOC100053018	Histone H4. (103 aa)
	LOC100052511	Histone H4. (103 aa)
	PXDNL	Peroxidasin like. (1243 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CALML4	Calmodulin like 4. (197 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (321 aa)
	NFATC4	Nuclear factor of activated T cells 4. (932 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
	LOC102148494	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM1	CALML3	ENSECAP00000007162	ENSECAP00000004472	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin like 3; Belongs to the calmodulin family.	0.935
CALM1	CALML4	ENSECAP00000007162	ENSECAP00000019278	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin like 4.	0.937
CALM1	CALML5	ENSECAP00000007162	ENSECAP00000031692	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin like 5.	0.951
CALM1	CASQ1	ENSECAP00000007162	ENSECAP00000017609	Uncharacterized protein; Belongs to the calmodulin family.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.707
CALM1	CASQ2	ENSECAP00000007162	ENSECAP00000045416	Uncharacterized protein; Belongs to the calmodulin family.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.747
CALM1	EGFR	ENSECAP00000007162	ENSECAP00000035347	Uncharacterized protein; Belongs to the calmodulin family.	Receptor protein-tyrosine kinase.	0.497
CALM1	GAPDH	ENSECAP00000007162	ENSECAP00000019665	Uncharacterized protein; Belongs to the calmodulin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.574
CALM1	NFATC4	ENSECAP00000007162	ENSECAP00000008982	Uncharacterized protein; Belongs to the calmodulin family.	Nuclear factor of activated T cells 4.	0.547
CALM1	PXDN	ENSECAP00000007162	ENSECAP00000040420	Uncharacterized protein; Belongs to the calmodulin family.	Peroxidasin.	0.473
CALM1	PXDNL	ENSECAP00000007162	ENSECAP00000020314	Uncharacterized protein; Belongs to the calmodulin family.	Peroxidasin like.	0.473
CALML3	CALM1	ENSECAP00000004472	ENSECAP00000007162	Calmodulin like 3; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.935
CALML3	CALML4	ENSECAP00000004472	ENSECAP00000019278	Calmodulin like 3; Belongs to the calmodulin family.	Calmodulin like 4.	0.936
CALML3	CALML5	ENSECAP00000004472	ENSECAP00000031692	Calmodulin like 3; Belongs to the calmodulin family.	Calmodulin like 5.	0.951
CALML3	CASQ1	ENSECAP00000004472	ENSECAP00000017609	Calmodulin like 3; Belongs to the calmodulin family.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.722
CALML3	CASQ2	ENSECAP00000004472	ENSECAP00000045416	Calmodulin like 3; Belongs to the calmodulin family.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.740
CALML3	EGFR	ENSECAP00000004472	ENSECAP00000035347	Calmodulin like 3; Belongs to the calmodulin family.	Receptor protein-tyrosine kinase.	0.497
CALML3	GAPDH	ENSECAP00000004472	ENSECAP00000019665	Calmodulin like 3; Belongs to the calmodulin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.541
CALML3	NFATC4	ENSECAP00000004472	ENSECAP00000008982	Calmodulin like 3; Belongs to the calmodulin family.	Nuclear factor of activated T cells 4.	0.551
CALML3	PXDN	ENSECAP00000004472	ENSECAP00000040420	Calmodulin like 3; Belongs to the calmodulin family.	Peroxidasin.	0.473
CALML3	PXDNL	ENSECAP00000004472	ENSECAP00000020314	Calmodulin like 3; Belongs to the calmodulin family.	Peroxidasin like.	0.486