STRINGSTRING
TBP TBP ALK ALK RUNX1 RUNX1 SOCS3 SOCS3 PALMD PALMD IL4 IL4 HS6ST2 HS6ST2 NOTCH2 NOTCH2 JAK3 JAK3 ALB ALB CAV1 CAV1 CD86 CD86 PAX5 PAX5 BCR BCR SSBP2 SSBP2 EPO EPO STAT3 STAT3 ETV6 ETV6 STRN3 STRN3 SOCS2 SOCS2 STAT1 STAT1 ABL1 ABL1 RDX RDX LMO2 LMO2 GATA3 GATA3 IL9 IL9 SLC26A4 SLC26A4 GAPDH GAPDH GSDME GSDME SLC36A4 SLC36A4 TYK2 TYK2 IL13RA1 IL13RA1 JAK1 JAK1 EZR EZR SEC31A SEC31A TBX21 TBX21 IL2 IL2 JAK2 JAK2 STAT6 STAT6 IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBPTATA-box binding protein. (329 aa)
ALKTyrosine-protein kinase receptor. (1623 aa)
RUNX1RUNX family transcription factor 1. (537 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PALMDPalmdelphin. (551 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
HS6ST2Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (650 aa)
NOTCH2Notch receptor 2. (2471 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CD86CD86 molecule. (335 aa)
PAX5Paired box 5. (389 aa)
BCRBCR activator of RhoGEF and GTPase. (1325 aa)
SSBP2Single stranded DNA binding protein 2. (373 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ETV6ETS variant 6. (452 aa)
STRN3Striatin 3. (797 aa)
SOCS2Suppressor of cytokine signaling 2. (270 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RDXRadixin. (625 aa)
LMO2LIM domain only 2. (309 aa)
GATA3GATA binding protein 3. (445 aa)
IL9Interleukin 9. (147 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (780 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
GSDMEGasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. (497 aa)
SLC36A4Solute carrier family 36 member 4. (505 aa)
TYK2Tyrosine-protein kinase. (1262 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
EZREzrin. (830 aa)
SEC31ASEC31 homolog A, COPII coat complex component. (1265 aa)
TBX21T-box transcription factor 21. (535 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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