Caspase-3-like protein; Belongs to the peptidase C14A family.

Caspase 8; Belongs to the peptidase C14A family.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Caspase 9; Belongs to the peptidase C14A family.

Caspase-3-like protein; Belongs to the peptidase C14A family.

C-X-C motif chemokine.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Glyceraldehyde-3-phosphate dehydrogenase.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Interferon beta; Has antiviral, antibacterial and anticancer activities.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]

Caspase-3-like protein; Belongs to the peptidase C14A family.

Interferon regulatory factor 3.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Toll-like receptor 4.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Signal transducer and activator of transcription.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Signal transducer and activator of transcription.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Toll-like receptor.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]

Caspase-3-like protein; Belongs to the peptidase C14A family.

Toll like receptor 3; Belongs to the Toll-like receptor family.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]

Caspase-3-like protein; Belongs to the peptidase C14A family.

Toll-like receptor.

Caspase-3-like protein; Belongs to the peptidase C14A family.

Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]