STRINGSTRING
COL11A1 COL11A1 SGK1 SGK1 AURKA AURKA PDPK1 PDPK1 PLD1 PLD1 BCL2 BCL2 PRKCA PRKCA EGFR EGFR PLEK PLEK HDAC7 HDAC7 CAMKK2 CAMKK2 IGF1 IGF1 CD44 CD44 BRAF BRAF LATS2 LATS2 NDRG1 NDRG1 MTDH MTDH ERBB2 ERBB2 HDAC9 HDAC9 HDAC4 HDAC4 PLEK2 PLEK2 CDK4 CDK4 FOXO3 FOXO3 CASP3 CASP3 HDAC5 HDAC5 TSC2 TSC2 ROCK1 ROCK1 SAV1 SAV1 KRAS KRAS PLK1 PLK1 PTGS2 PTGS2 PTEN PTEN CCN2 CCN2 PIK3CA PIK3CA PLD2 PLD2 SRC SRC EGF EGF TEAD1 TEAD1 FABP5 FABP5 YAP1 YAP1 FOXO1 FOXO1 LATS1 LATS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (423 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (585 aa)
PLD1Phospholipase. (1189 aa)
BCL2BCL2 apoptosis regulator. (285 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
PLEKPleckstrin. (362 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (990 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (578 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
CD44CD44 antigen. (700 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
NDRG1N-myc downstream regulated 1. (384 aa)
MTDHMetadherin. (615 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1162 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1170 aa)
PLEK2Pleckstrin 2. (362 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FOXO3Forkhead box O3. (671 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa)
TSC2TSC complex subunit 2. (1817 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
PTENPhosphatase and tensin homolog. (576 aa)
CCN2Cellular communication network factor 2. (475 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD2Phospholipase. (933 aa)
SRCTyrosine-protein kinase. (551 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
TEAD1TEA domain transcription factor 1. (437 aa)
FABP5Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (158 aa)
YAP1Yes associated protein 1. (508 aa)
FOXO1Forkhead box O1. (651 aa)
LATS1Large tumor suppressor kinase 1. (1128 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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