STRINGSTRING
ZEB1 ZEB1 STAT3 STAT3 EGFR EGFR IFNG IFNG SMAD2 SMAD2 SMAD4 SMAD4 PDCD1 PDCD1 PXDNL PXDNL GAPDH GAPDH KRAS KRAS IRF1 IRF1 ACTB ACTB FGF2 FGF2 MMP9 MMP9 CDH2 CDH2 SNAI2 SNAI2 SNAI1 SNAI1 OCLN OCLN ALK ALK MUC1 MUC1 CTLA4 CTLA4 SMAD3 SMAD3 VIM VIM PXDN PXDN TWIST1 TWIST1 MMP3 MMP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZEB1Zinc finger E-box binding homeobox 1. (1124 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
SMAD2Mothers against decapentaplegic homolog. (610 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PDCD1Programmed cell death 1. (287 aa)
PXDNLPeroxidasin like. (1243 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IRF1Interferon regulatory factor 1. (423 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
MMP9Matrix metallopeptidase 9. (714 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SNAI1Snail family transcriptional repressor 1. (265 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (520 aa)
ALKTyrosine-protein kinase receptor. (1623 aa)
MUC1Mucin 1, cell surface associated. (714 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
VIMVimentin; Belongs to the intermediate filament family. (495 aa)
PXDNPeroxidasin. (1596 aa)
TWIST1Twist 1. (199 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (477 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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