STRINGSTRING
LOC111767413 LOC111767413 LOC102149380 LOC102149380 LOC111768663 LOC111768663 LOC100067178 LOC100067178 TLR6 TLR6 TNF TNF CTLA4 CTLA4 MUC1 MUC1 IL10 IL10 CD4 CD4 IL2 IL2 IRX2 IRX2 TLR2 TLR2 TLR1 TLR1 IFNG IFNG TLR3 TLR3 TP53 TP53 CD80 CD80 CD86 CD86 LOC100049805 LOC100049805 TGFB2 TGFB2 LOC100055651 LOC100055651 LOC100050711 LOC100050711
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111767413Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
LOC102149380SERPIN domain-containing protein; Belongs to the serpin family. (385 aa)
LOC111768663Peptidase S1 domain-containing protein. (255 aa)
LOC100067178Uncharacterized protein. (408 aa)
TLR6Toll-like receptor. (859 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
MUC1Mucin 1, cell surface associated. (714 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CD4CD4 molecule. (460 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
IRX2Iroquois homeobox 2. (473 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TLR1Toll-like receptor. (756 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
CD80CD80 molecule. (305 aa)
CD86CD86 molecule. (335 aa)
LOC100049805Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC100055651Peptidase S1 domain-containing protein. (244 aa)
LOC100050711Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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