(11 nodes) (2018) Further characterization of adult sheep ovarian stem cells and their involvement in neo-oogenesis and follicle assembly. network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	NUMB	NUMB endocytic adaptor protein. (674 aa)
	AMH	Anti-Mullerian hormone. (573 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	GDF9	Growth differentiation factor 9. (451 aa)
	NUMBL	NUMB like endocytic adaptor protein. (592 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	NANOG	Homeobox domain-containing protein. (310 aa)
	SOX2	SRY-box transcription factor 2. (321 aa)
	LHX8	LIM homeobox 8. (375 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	GAPDH	ENSECAP00000041304	ENSECAP00000019665	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.965
ALB	NANOG	ENSECAP00000041304	ENSECAP00000010460	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Homeobox domain-containing protein.	0.858
ALB	SOX2	ENSECAP00000041304	ENSECAP00000008624	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	SRY-box transcription factor 2.	0.584
ALB	STAT3	ENSECAP00000041304	ENSECAP00000036035	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Signal transducer and activator of transcription.	0.781
AMH	GDF9	ENSECAP00000044331	ENSECAP00000018542	Anti-Mullerian hormone.	Growth differentiation factor 9.	0.827
GAPDH	ALB	ENSECAP00000019665	ENSECAP00000041304	Glyceraldehyde-3-phosphate dehydrogenase.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.965
GAPDH	NANOG	ENSECAP00000019665	ENSECAP00000010460	Glyceraldehyde-3-phosphate dehydrogenase.	Homeobox domain-containing protein.	0.807
GAPDH	SOX2	ENSECAP00000019665	ENSECAP00000008624	Glyceraldehyde-3-phosphate dehydrogenase.	SRY-box transcription factor 2.	0.725
GAPDH	STAT3	ENSECAP00000019665	ENSECAP00000036035	Glyceraldehyde-3-phosphate dehydrogenase.	Signal transducer and activator of transcription.	0.878
GDF9	AMH	ENSECAP00000018542	ENSECAP00000044331	Growth differentiation factor 9.	Anti-Mullerian hormone.	0.827
GDF9	LHX8	ENSECAP00000018542	ENSECAP00000004040	Growth differentiation factor 9.	LIM homeobox 8.	0.625
LHX8	GDF9	ENSECAP00000004040	ENSECAP00000018542	LIM homeobox 8.	Growth differentiation factor 9.	0.625
NANOG	ALB	ENSECAP00000010460	ENSECAP00000041304	Homeobox domain-containing protein.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.858
NANOG	GAPDH	ENSECAP00000010460	ENSECAP00000019665	Homeobox domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.807
NANOG	SOX2	ENSECAP00000010460	ENSECAP00000008624	Homeobox domain-containing protein.	SRY-box transcription factor 2.	0.978
NANOG	STAT3	ENSECAP00000010460	ENSECAP00000036035	Homeobox domain-containing protein.	Signal transducer and activator of transcription.	0.977
NUMB	NUMBL	ENSECAP00000045293	ENSECAP00000015008	NUMB endocytic adaptor protein.	NUMB like endocytic adaptor protein.	0.903
NUMBL	NUMB	ENSECAP00000015008	ENSECAP00000045293	NUMB like endocytic adaptor protein.	NUMB endocytic adaptor protein.	0.903
SOX2	ALB	ENSECAP00000008624	ENSECAP00000041304	SRY-box transcription factor 2.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.584
SOX2	GAPDH	ENSECAP00000008624	ENSECAP00000019665	SRY-box transcription factor 2.	Glyceraldehyde-3-phosphate dehydrogenase.	0.725