(10 nodes) (2018) Zinc stimulates glucose oxidation and glycemic control by modulating the insulin signaling pathway in human and mouse skeletal muscle cell lines. network (Equus caballus)

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Your Input:
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	IRS2	Insulin receptor substrate 2. (1401 aa)
	IRS1	Insulin receptor substrate 1. (1239 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	PXDNL	Peroxidasin like. (1243 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC100069009	Uncharacterized protein. (571 aa)
	PXDN	Peroxidasin. (1596 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAPDH	INS	ENSECAP00000019665	ENSECAP00000022114	Glyceraldehyde-3-phosphate dehydrogenase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.929
GAPDH	INSR	ENSECAP00000019665	ENSECAP00000008032	Glyceraldehyde-3-phosphate dehydrogenase.	Tyrosine-protein kinase receptor.	0.413
GAPDH	IRS1	ENSECAP00000019665	ENSECAP00000005422	Glyceraldehyde-3-phosphate dehydrogenase.	Insulin receptor substrate 1.	0.660
GAPDH	MTOR	ENSECAP00000019665	ENSECAP00000049618	Glyceraldehyde-3-phosphate dehydrogenase.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.411
GAPDH	PXDN	ENSECAP00000019665	ENSECAP00000040420	Glyceraldehyde-3-phosphate dehydrogenase.	Peroxidasin.	0.974
GAPDH	PXDNL	ENSECAP00000019665	ENSECAP00000020314	Glyceraldehyde-3-phosphate dehydrogenase.	Peroxidasin like.	0.974
GAPDH	SLC2A4	ENSECAP00000019665	ENSECAP00000006413	Glyceraldehyde-3-phosphate dehydrogenase.	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.855
INS	GAPDH	ENSECAP00000022114	ENSECAP00000019665	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glyceraldehyde-3-phosphate dehydrogenase.	0.929
INS	INSR	ENSECAP00000022114	ENSECAP00000008032	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.999
INS	IRS1	ENSECAP00000022114	ENSECAP00000005422	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 1.	0.994
INS	IRS2	ENSECAP00000022114	ENSECAP00000002251	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2.	0.988
INS	LOC100069009	ENSECAP00000022114	ENSECAP00000038151	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.992
INS	MTOR	ENSECAP00000022114	ENSECAP00000049618	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.676
INS	PXDN	ENSECAP00000022114	ENSECAP00000040420	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Peroxidasin.	0.920
INS	PXDNL	ENSECAP00000022114	ENSECAP00000020314	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Peroxidasin like.	0.920
INS	SLC2A4	ENSECAP00000022114	ENSECAP00000006413	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.966
INSR	GAPDH	ENSECAP00000008032	ENSECAP00000019665	Tyrosine-protein kinase receptor.	Glyceraldehyde-3-phosphate dehydrogenase.	0.413
INSR	INS	ENSECAP00000008032	ENSECAP00000022114	Tyrosine-protein kinase receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.999
INSR	IRS1	ENSECAP00000008032	ENSECAP00000005422	Tyrosine-protein kinase receptor.	Insulin receptor substrate 1.	0.989
INSR	IRS2	ENSECAP00000008032	ENSECAP00000002251	Tyrosine-protein kinase receptor.	Insulin receptor substrate 2.	0.990